Texas A&M University Department of Biology
  • B.A., 1977, Pomona College, Physics.
  • Ph.D., 1983, Caltech, Biology.
  • Postdoctoral research, University of California, San Diego.
  • Previous faculty appointments: Rice University, Baylor College of Medicine, Howard Hughes Medical Institute.

Joined the department in 2010.

Gomer Lab Website

Richard Gomer

Richard Gomer

3258 TAMU
College Station, TX 77843-3258

3258 TAMU
Interdisciplinary Life Sciences Building
Room 2121B

Interdisciplinary Life Sciences Building
Room 2121

Fax: 979-845-2891
Email: rgomer@bio.tamu.edu

Curriculum Vitae

Tissue size regulation, wound healing, and fibrosing diseases

Our laboratory is working on two areas of biomedicine. First, we are studying how the sizes of tissues and tumors are regulated, and how this can be manipulated for therapeutic purposes. As a model system, we are using the simple eukaryote Dictyostelium discoideum, which allows us to combine techniques such as biochemistry, genetics, computer modeling, and cell biology to study tissue size regulation. We have found that a secreted protein is the signal in a negative feedback loop that inhibits Dictyostelium cell proliferation, and we are studying the signal transduction pathway to understand similar mechanisms in humans.

Second, we have found that a human blood protein called Serum Amyloid P (SAP) regulates a key step in the formation of scar tissue as well as the formation of the scar-like lesions in fibrosing diseases such as congestive heart failure and pulmonary fibrosis. We are studying this mechanism, as well as working with two biotech companies to develop a new wound-healing material and a therapy for fibrosing diseases, both based on manipulating SAP levels.

  1. Herlihy SE, Brown ML, Pilling D, Weeks BR, Myers LK & Gomer RH (2015) Soluble dipeptidyl peptidase IV decreases inflammation in a murine model of arthritis. Arthritis Rheumatol 0: Full text
  2. White MJ, Roife D & Gomer RH (2015) Galectin-3 Binding Protein Secreted by Breast Cancer Cells Inhibits Monocyte-Derived Fibrocyte Differentiation. J Immunol 0: Full text
  3. Cox N, Pilling D & Gomer RH (2015) DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice. Proc Natl Acad Sci U S A 112:8385-90 Full text
  4. Pilling D, Cox N, Vakil V, Verbeek JS & Gomer RH (2015) The long pentraxin PTX3 promotes fibrocyte differentiation. PLoS One 10:e0119709 Full text
  5. Phillips JE & Gomer RH (2015) Partial genetic suppression of a loss-of-function mutant of the neuronal ceroid lipofuscinosis-associated protease TPP1 in Dictyostelium discoideum. Dis Model Mech 8:147-56 Full text
  6. Pilling D, Zheng Z, Vakil V & Gomer RH (2014) Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis. Proc Natl Acad Sci U S A 111:18291-6 Full text
  7. White MJ, Galvis-Carvajal E & Gomer RH (2015) A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p. J Immunol 194:142-50 Full text
  8. Cox N, Pilling D & Gomer RH (2014) Distinct Fcγ receptors mediate the effect of serum amyloid p on neutrophil adhesion and fibrocyte differentiation. J Immunol 193:1701-8 Full text
  9. DeBord JD, Smith DF, Anderton CR, Heeren RM, Paša-Tolić L, Gomer RH & Fernandez-Lima FA (2014) Secondary ion mass spectrometry imaging of Dictyostelium discoideum aggregation streams. PLoS One 9:e99319 Full text
  10. Cox N, Pilling D & Gomer RH (2014) Serum amyloid P: a systemic regulator of the innate immune response. J Leukoc Biol 96:739-43 Full text

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