Texas A&M University Department of Biology
  • B.A., 1977, Pomona College, Physics.
  • Ph.D., 1983, Caltech, Biology.
  • Postdoctoral research, University of California, San Diego.
  • Previous faculty appointments: Rice University, Baylor College of Medicine, Howard Hughes Medical Institute.

Joined the department in 2010.

Gomer Lab Website

Richard Gomer

Richard Gomer
Professor

3258 TAMU
College Station, TX 77843-3258

Office:
3258 TAMU
Interdisciplinary Life Sciences Building
Room 2121B
979-458-5745

Lab:
Interdisciplinary Life Sciences Building
Room 2121
979-458-5750

Fax: 979-845-2891
Email: rgomer@bio.tamu.edu

Curriculum Vitae

Tissue size regulation, wound healing, and fibrosing diseases

Our laboratory is working on two areas of biomedicine. First, we are studying how the sizes of tissues and tumors are regulated, and how this can be manipulated for therapeutic purposes. As a model system, we are using the simple eukaryote Dictyostelium discoideum, which allows us to combine techniques such as biochemistry, genetics, computer modeling, and cell biology to study tissue size regulation. We have found that a secreted protein is the signal in a negative feedback loop that inhibits Dictyostelium cell proliferation, and we are studying the signal transduction pathway to understand similar mechanisms in humans.

Second, we have found that a human blood protein called Serum Amyloid P (SAP) regulates a key step in the formation of scar tissue as well as the formation of the scar-like lesions in fibrosing diseases such as congestive heart failure and pulmonary fibrosis. We are studying this mechanism, as well as working with two biotech companies to develop a new wound-healing material and a therapy for fibrosing diseases, both based on manipulating SAP levels.

  1. Cox N, Pilling D & Gomer RH (2014) Distinct fcγ receptors mediate the effect of serum amyloid p on neutrophil adhesion and fibrocyte differentiation. J Immunol 193:1701-8 Full text
  2. DeBord JD, Smith DF, Anderton CR, Heeren RM, Paša-Tolić L, Gomer RH & Fernandez-Lima FA (2014) Secondary ion mass spectrometry imaging of Dictyostelium discoideum aggregation streams. PLoS One 9:e99319 Full text
  3. Cox N, Pilling D & Gomer RH (2014) Serum amyloid P: a systemic regulator of the innate immune response. J Leukoc Biol 9:e99319 Full text
  4. Phillips JE & Gomer RH (2014) The p21-activated kinase (PAK) family member PakD is required for chemorepulsion and proliferation inhibition by autocrine signals in Dictyostelium discoideum. PLoS One 9:e96633 Full text
  5. Pilling D, Crawford JR, Verbeek JS & Gomer RH (2014) Inhibition of murine fibrocyte differentiation by cross-linked IgG is dependent on FcγRI. J Leukoc Biol 96:275-82 Full text
  6. Pilling D & Gomer RH (2014) Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice. PLoS One 9:e93730 Full text
  7. Bakthavatsalam D, White MJ, Herlihy SE, Phillips JE & Gomer RH (2014) A retinoblastoma orthologue is required for the sensing of a chalone in Dictyostelium discoideum. Eukaryot Cell 13:376-82 Full text
  8. Gomer RH (2013) New approaches to modulating idiopathic pulmonary fibrosis. Curr Allergy Asthma Rep 13:607-12 Full text
  9. White MJ, Glenn M & Gomer RH (2013) Trypsin potentiates human fibrocyte differentiation. PLoS One 8:e70795 Full text
  10. Herlihy SE, Pilling D, Maharjan AS & Gomer RH (2013) Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent. J Immunol 190:6468-77 Full text

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