- B.S., 1975, University of Calfornia, Davis, Zoology.
- Ph.D., 1980, University of California, Berkeley, Zoology.
- Postdoctoral research: University of Alberta.
Joined the department in 1983.
College Station, TX 77843-3258
Biological Sciences Building East
Biological Sciences Building East
|Comparative Endocrinology of Thyroid Function
Hormones secreted by the thyroid gland are of primary importance in the regulation of such fundamental physiological processes as growth, nutrient utilization, and reproduction. In my laboratory, we examine the regulation of the secretion of thyroid hormones and their actions in poikilothermic vertebrates in order to understand the evolution of thyroid function. We are presently focusing on the relationship between nutrient intake and thyroid hormone secretion in commercially-important fish species such as the red drum (Sciaenops ocellatus) and the channel catfish (Ictalurus punctatus).
We have demonstrated that both quantity and quality of food intake alter the production of thyroid hormones, and that thyroid hormone administration has significant effects on the metabolism of protein and lipid. Changes in blood protein composition associated with nutrient mobilization for reproduction also alter thyroid hormone delivery to target cells. We have recently discovered that blood thyroxine levels undergo robust daily cycles in the red drum, supporting a role for an endogenous clock in the central control of thyroid hormone production. Future studies will be directed towards examining the regulation of thyroid hormone cycles and determining their physiological significance. I also intend to examine the specific mechanisms through which nutrient intake influences thyroid hormone secretion, and the manner in which thyroid hormone delivery to target tissues is influenced by circulatory factors unique to poikilotherms.
A comparative perspective is always maintained in my research. Because of their position at the transition to endothermy, reptiles remain an interesting model for the examination of thyroid hormone action. For this reason, I also direct research on endocrine function in reptiles, such as sea turtles, desert tortoises, and alligators. From these animals we gain a broader perspective of the relationship between nutrient intake, temperature, and thyroid hormone production.
This research is aimed at providing new insights into the potentially ancient role of thyroid hormones in nutrient assimilation, as well as elucidating evolutionary trends in the regulation of thyroid function. These studies may serve identify ways in which the pituitary-thyroid axis may be manipulated to enhance aquaculture production or endangered species conservation.
- Martinez B, Soñanez-Organis JG, Vázquez-Medina JP, Viscarra JA, Mackenzie DS, Crocker DE & Ortiz RM (2013) Prolonged food deprivation increases mRNA expression of deiodinase 1 and 2, and thyroid hormone receptor β-1 in a fasting-adapted mammal. J Exp Biol 216:4647-54 Full text
- Jones RA, Cohn WB, Miller TC, Jaques JT & Mackenzie DS (2013) Cyclic mRNA expression of thyrotropin subunits and deiodinases in red drum, Sciaenops ocellatus. Gen Comp Endocrinol 194:248-56 Full text
- Pohlenz C, Buentello A, Miller T, Small BC, MacKenzie DS & Gatlin DM 3rd (2013) Effects of dietary arginine on endocrine growth factors of channel catfish, Ictalurus punctatus. Comp Biochem Physiol A Mol Integr Physiol 166:215-21 Full text
- Browning ZS, Wilkes AA, Mackenzie DS, Patterson RM & Lenox MW (2013) Using PET/CT imaging to characterize 18 F-fluorodeoxyglucose utilization in fish. J Fish Dis 36:911-9 Full text
- Miller TC, Jaques JT, Szkudlinski MW & Mackenzie DS (2012) Thyrotropic activity of recombinant human glycoprotein hormone analogs and pituitary mammalian gonadotropins in goldfish (Carassius auratus): insights into the evolution of thyrotropin receptor specificity. Gen Comp Endocrinol 177:70-5 Full text
- Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y & Mauro TM (2012) SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease. J Invest Dermatol 132:1188-95 Full text
- Rodriguez-Martin M, Martin-Ezquerra G, Man MQ, Hupe M, Youm JK, Mackenzie DS, Cho S, Trullas C, Holleran WM, Radek KA & Elias PM (2011) Expression of epidermal CAMP changes in parallel with permeability barrier status. J Invest Dermatol 131:2263-70 Full text
- Scobell SK & Mackenzie DS (2011) Reproductive endocrinology of Syngnathidae. J Fish Biol 78:1662-80 Full text
- Martin-Ezquerra G, Man MQ, Hupe M, Rodriguez-Martin M, Youm JK, Trullas C, Mackenzie DS, Radek KA, Holleran WM & Elias PM (2011) Psychological stress regulates antimicrobial peptide expression by both glucocorticoid and β-adrenergic mechanisms. Eur J Dermatol 21 Suppl 2:48-51 Full text
- Celli A, Mackenzie DS, Crumrine DS, Tu CL, Hupe M, Bikle DD, Elias PM & Mauro TM (2011) Endoplasmic reticulum Ca2+ depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis. Br J Dermatol 164:16-25 Full text