Texas A&M University Department of Biology
  • B.S., 1995  Abilene Christian University
  • Ph.D., 2000 Baylor College of Medicine
  • Postdoc, 2000-2004  Harvard University

Joined the Department in 2004
Awards: 
2001-2004                   NRSA Post-doctoral Fellowship
1996-1999                   NRSA Training Grant Pre-doctoral Fellow: 
1995                            Paul C. Witt Award, Abilene ChristianUniversity.
1995                            Summa Cum Laude, Abilene Christian University
1995                            University Scholar, Abilene Christian University

Perkins Lab Website

Brian Perkins

Brian Perkins
Associate Professor

3258 TAMU
College Station, TX 77843-3258

Office:
Biological Sciences Building East
Room 118C
979-845-6505

Lab:
Biological Sciences Building East
Room 102
979-845-3655

Fax: 979-845-2891
Email: bperkins@bio.tamu.edu

Curriculum Vitae

Genetic Studies of Retinal Development in Vertebrates

Zebrafish RetinaDr. Perkins investigates the cell biology of hereditary blindness to understand the causes of photoreceptor degeneration.  His lab uses zebrafish to investigate the mechanisms underlying photoreceptor morphogenesis, intracellular trafficking, and retinal pigment epithelium (RPE) function.  The small size and rapid development of zebrafish enable his lab to efficiently and rapidly conduct many experiments in a small amount of space and as a vertebrate, the genetic pathways, physiology, and anatomy of the retina is very similar to humans.  Thus, what he learns from the studies in zebrafish will be applicable to understanding the pathways leading to retinal disease in humans.  The lab currently focuses on defects in various tissues resulting from loss of function in genes required for cilia formation and function.  Specifically, we use mutants and loss of function strategies (e.g. morpholino oligonucleotides) to study how Intraflagellar Transport (IFT) affects photoreceptor outer segment formation.  The long term goal is to understand how defects in cilia formation and intracellular trafficking cause vision loss in diseases such as Age Related Macular Degeneration, Bardet-Biedl Syndrome and Retinitis Pigmentosa.

  1. Krock BL & Perkins BD (2014) The Par-PrkC Polarity Complex Is Required for Cilia Growth in Zebrafish Photoreceptors. PLoS One 9:e104661 Full text
  2. Wasfy MM, Matsui JI, Miller J, Dowling JE & Perkins BD (2014) myosin 7aa(-/-) mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses. Exp Eye Res 122:65-76 Full text
  3. Ramsey M & Perkins BD (2013) Basal bodies exhibit polarized positioning in zebrafish cone photoreceptors. J Comp Neurol 521:1803-16 Full text
  4. Perkins BD & Fadool JM (2010) Photoreceptor structure and development analyses using GFP transgenes. Methods Cell Biol 100:205-18 Full text
  5. Hudak LM, Lunt S, Chang CH, Winkler E, Flammer H, Lindsey M & Perkins BD (2010) The intraflagellar transport protein ift80 is essential for photoreceptor survival in a zebrafish model of jeune asphyxiating thoracic dystrophy. Invest Ophthalmol Vis Sci 51:3792-9 Full text
  6. Tobler M, Coleman SW, Perkins BD & Rosenthal GG (2010) Reduced opsin gene expression in a cave-dwelling fish. Biol Lett 6:98-101 Full text
  7. Lunt SC, Haynes T & Perkins BD (2009) Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling. Dev Dyn 238:1744-59 Full text
  8. Krock BL, Mills-Henry I & Perkins BD (2009) Retrograde intraflagellar transport by cytoplasmic dynein-2 is required for outer segment extension in vertebrate photoreceptors but not arrestin translocation. Invest Ophthalmol Vis Sci 50:5463-71 Full text
  9. Sukumaran S & Perkins BD (2009) Early defects in photoreceptor outer segment morphogenesis in zebrafish ift57, ift88 and ift172 Intraflagellar Transport mutants. Vision Res 49:479-89 Full text
  10. Krock BL & Perkins BD (2008) The intraflagellar transport protein IFT57 is required for cilia maintenance and regulates IFT-particle-kinesin-II dissociation in vertebrate photoreceptors. J Cell Sci 121:1907-15 Full text

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