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| Terry Thomas received his B.S. (1972) and Ph.D. (1975) from the University of Georgia. Following postdoctoral work as an NIH and American Cancer Society Fellow with Eric Davidson at the California Institute of Technology, he joined the Department of Biology in 1983. He was promoted to Associate Professor in 1988 and then to Professor in 1992. He served as Head of the Department of Biology from 1992-2002. Terry is a member of the Biological Clocks Program and the Molecular and Environmental Plant Science (MEPS) Faculty. Terry is the Director of the Laboratory for Functional Genomics. |
Terry Thomas 3258 TAMU Office: Lab: Fax: 979-847-8805 |
| Research Interests
My interests are evolutionarily broad and include animals, plants and fungi. A major focus of the lab is the genomic analysis of gene expression programs during plant gene expression programs, particularly during embryogenesis and seed development, and the underlying regulatory mechanisms required for the initiation and maintenance of these programs. This work has illustrated the combinatorial interactions of cis and trans -acting factors that result in specific gene regulatory events. We are also using genomics tools to study the interaction of the rice blast fungus, Magnaporthe grisea , with plant hosts; the circadian control of gene expression; and the development of the vertebrate retina. An additional focal area is the utilization of molecular and cellular approaches for crop improvement. As part of these research activities, we have developed or adapted high throughput genomics approaches to accelerate the gene discovery process and subsequent analysis of gene expression and function. |
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Mu, X., Fu, X., Beremand, P.D., Thomas, T.L. and Klein, W.H. 2008 Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2. Proc. Natl. Acad. Sci., In press. Roux, C., Rolan, H., Santos, R.,Beremand, P.,Thomas, T., Adams, L., Tsolis, R. 2007. Brucella requires a functional Type IV secretion system to elicit innate immune responses in mice. Cellular Microbiology, 9, 1851-1869. Menger, G., Allen, G., Neuendorff, N., Nahm, S.-S., Thomas, T., Cassone, V., Earnest, D. 2007. Circadian Profiling of the Transcriptome in NIH/3T3 Fibroblasts: Comparison with Rhythmic Gene Expression in SCN2.2 Cells and the Rat SCN. Physiological Genomics, 29, 280-289. Gray, C.A., Abbery, C.A., Beremand, P.D., Choi, Y., Farmer, J.L., Adelson, D.L., Thomas, T.L., Bazer, F.W., Spencer, T.E. 2006. Transcriptional profiling of endometrial responses to early pregnancy in sheep. Biology of Reproduction 74,383-394. Finkelstein, R., Gampala, S., Lynch, T., Thomas, T. and Rock, C. 2005. Redundant and distinct functions of the ABA response loci ABA-INSENSITIVE(ABI)5 and ABRE-BINDING FACTOR(ABF)3. Plant Molecular Biology 59, 253-267. Bell-Pedersen, D., Cassone, V.M., Earnest, D.J., Golden, S.S., Hardin, P.E., Thomas, T.L., and Zoran, M.J. 2005. The regulation of circadian rhythmicity by multiple oscillators: lessons from diverse organisms. Nature Reviews Genetics 6, 544-556. Menger, G.J., Lu, K., Thomas, T.L., Cassone, V.M., Earnest, D.J. 2005. Circadian profiling of the transcriptome on immortalized rat SCN cells. Physiological Genomics 21, 370 - 381. Holtman C.K., Chen, Y, Sandoval, P., Gonzales, A., Nalty, M.S., Thomas, T.L., Youderian, P., and Golden, SS. 2005. High-throughput functional analysis of the Synechococcus elongatus PCC 7942 genome. DNA Research 12, 103-115. Mu, X., Fu,X., Sun, H., Beremand, P.D., Thomas, T.L., and Klein, W.H. 2005. A Gene Network Downstream Of Transcription Factor Math5 Regulates Retinal Progenitor Cell Competence And Ganglion Cell Fate. Developmental Biology 280, 467-481. Chung, H.J., Fu, H. Y. and Thomas, T.L. 2005. ABA inducible nuclear proteins bind to bipartite promoter elements required for ABA response and embryo regulated expression of the carrot Dc3 gene. Planta , 220 , 424-433. Ebbole, D.J., Yuan, J., Thon, M., Pan, H., Bhatterai, E., Thomas, T. and Dean, R. 2004. Gene discovery and gene expression in the rice blast fungus, Magnaporthe grisea : Analysis of expressed sequence tags. Molecular Plant-Microbe Interactions. 17 , 1337-1347. Liang, S., Zhao, S., Mu., X., Thomas, T. L. and Klein, W.H. Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database. 2004. Molecular Vision , 10 , 773-786. Bailey, M.J., Beremand, P., Hammer, R., Reidel, E., Thomas, T.L. and Cassone, V.M. 2004. Transcriptional profiling of circadian patterns of mRNA expression in the chick retina. J. Biol. Chem. 279 , 52247-52254. Mu, X., Beremand, P.D., Zhao, S., Pershad, R., Sun, H., Scarpa, A., Liang, S., Thomas, T.L., Klein, W.H. (2003) Discrete gene sets depend on POU transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina. Development 131 , 1197-1210. Bailey, M.J., Beremand, P.D., Hammer, R., Bell-Pedersen, D., Thomas, T.L. and Cassone, V.M. (2003) Transcriptional profiling of the chick pineal gland, a photoreceptive circadian oscillator and pacemaker. Molecular Endocrinology 17 , 2084-2095. Kim, S.Y., Ma, J., Perret, P., Li, Z. and Thomas, T.L. 2002. Arabidopsis ABI5 subfamily members have distinct DNA-binding and transcriptional activities. Plant Physiol. , 130 : 688-697. Lewis, Z.A., Correa, A., Schwerdtfeger, C., Link, K.L., Xie, X., Gomer, R.H., Thomas, T., Ebbole, D.J. and Bell-Pedersen, D. 2002. Overexpression of WHITE COLLAR-1(WC-1) activates circadian clock-associated genes, but is not sufficient to induce light-regulated gene expression in Neurospora crassa . Molecular Microbiology , 45: 917-931. Chuang, H.-W.,Hsieh, T.-F., Duval, M and Thomas, T.L. 2002. Genomic analysis of Arabidopsis gene expression in response to a systemic fungicide. In Genomics of Plants and Fungi, (eds. R.A. Prade and H.J.Bohnert), Marcel Dekker, Inc., New York. pp 237-253. Duval, M., Hsieh, T.F., Kim, S.Y. and Thomas, T.L. 2002. Molecular characterization of AtNAM : A member of the Arabidopsis NAC domain superfamily. Plant Molecular Biology , 50: 237-248. Qui, X., Hong, H., Datla, N., MacKenzie, S.L., Taylor, D.C., and Thomas, T.L. 2002. Expression of borage delta-6 -desaturase in Saccharomyces cerevisiae and oilseed crops. Canadian Journal of Botany 80 , 42-49. Patents Chimeric Plant Genes Based on Upstream Regulatory Elements of Helianthinin T. Thomas, M. Bogue, M LeBrun and G. Freyssinet. USPTO Patent Nos. 5,824,865 (10/20/98), 5,859,325 (1/12/99), 5,905,186 (5/18/99). Production of Gamma Linolenic Acid by a delta-6 -Desaturase T. Thomas, A.S Reddy, M. Nuccio and G. Freyssinet. USPTO Patent Nos. 5,552,306 (9/3/96); 5,614,393 (3/25/97); 5,663,068 (9/2/97); 5,789,220 (8/4/98). Several other patents dealing with delta-6 -desaturase genes from various sources and with novel promoters we have developed have also been issued.
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