Xiaorong Lin (PI)
Srijana Upadhyay (research assoc.)
Nadia Chacko (postdoc)
Xiuyun Tian (postdoc)
Linqi Wang (postdoc)
Rachana Gyawali(grad student)
Bing Zhai (grad student)
Dylan Foyle (undergrad)
Angelyn Hilton (undergrad)
Gail Pereira (undergrad)
Guadalupe Torres (undergrad)
Xiuyun Tian received her PhD degree in Biochemistry and Molecular Microbiology under the supervision of Dr. Keqian Yang from the Institute of Microbiology, Chinese Academy of Sciences (CAS). During her Ph.D. years, she mainly focused on the biological significance of the interaction between physiologically active small molecules and regulatory proteins. She also applied structural biology and biochemistry to rationally mutagenize enzymes of commercial significance. As a Ph.D. candidate, she was awarded Director Scholarship of IMCAS, “Procter & Gamble” Scholarship and Graduate University of CAS Excellent Students Awards. Now she is working on the communication between nucleus and mitochondrion during development and differentiation in Cryptococcus neoformans.
Publications: (# co-first author)
Ji J#, Tian X#, Fan K, Yang K*. In press. New strategy of site-directed mutagenesis identifies new sites to improve Streptomyces clavuligerus deacetoxycephalosporin C synthase activity toward penicillin G. Appl Microbiol Biotechnol.
Wu X#, Tian X#, Ji J, Wu W, Fan K, Yang K*. (2011) Saturation mutations of R308 of Acremonium chrysogenum deacetoxy/deacetylcephalosporin C synthase with improved activity toward penicillin analogs. Biotechnol Lett. Apr; 33(4):805-12.
Xu G, Wang J, Wang L, Tian X, Yang H, Fan K, Yang K, and Tan H (2010). 'Pseudo' gamma-butyrolactone receptors respond to antibiotic signals to coordinate antibiotics biosynthesis. J Biol Chem. 285(35):27440-8.
Wang L#, Tian X#, Wang J, Yang H, Fan K, Xu G, Yang K*, and Tan H*. (2009) Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator. PNAS 106 (21): 8617-22.