RESEARCH

1. Fungal pathogenesis
---Cryptococcus neoformans
---Aspergillus fumigatus
2. Antifungal discovery

PUBLICATIONS

TEACHING

LAB MEMBERS

Xiaorong Lin (PI)
Srijana Upadhyay (research assoc.)   
Nadia Chacko (postdoc)
Xiuyun Tian (postdoc)
Linqi Wang (postdoc)
Rachana Gyawali(grad student)
Bing Zhai (grad student)
Dylan Foyle (undergrad)
Angelyn Hilton (undergrad)
Gail Pereira (undergrad)
Guadalupe Torres (undergrad)

LAB PHOTOS

Linqi Wang Post-Doctoral Fellow Contact information BSBW 435 3258 TAMU College Station, TX 77843-3258 Phone: 979-845-7259 Email: lqwang@bio.tamu.edu

Biography

Linqi Wang obtained his Ph.D from the Institute of Microbiology, Chinese Academy of Sciences (CAS).  Under the supervision of Dr. Huarong Tan at CAS, Linqi mostly focused on the characterization of regulatory and physiological roles of endogenous metabolites (mainly antibiotics) for his dissertation. As a graduate student, he received a couple of prestigious awards, including the CAS Presidential Scholarship, Director Scholarship of Institute of Microbiology, and several other fellowships. He was awarded as an Excellent Graduate Student of CAS. Linqi joined the Lin lab as a Post-Doctoral Fellow in July 2010 and switched his focus from bacteria to fungal pathogens. He is now in the process of discovering novel Cryptococcus neoformans virulence factors and relevant cellular and molecular mechanisms. 

Publications:

Wang L, Tian X, Gyawali R, and Lin X*.  (in press) An adhesin guides community behaviors and  autoinduction in fungi in a paracrinal manner. PNAS

Wang L and Lin X* (2012 ). Morphogenesis in fungal pathogenicity: Shape, size, and surface. PLoS Pathogens.  8(12): e1003027.

Wang L, Zhai B, and Lin X*. (2012) The link between morphotype transition and virulence in Cryptococcus neoformans. PLoS Pathogens.  8(6): e1002765.

Zhai B, Cheng W, Wang L, Sachs MS, and Lin X (2012). The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal infections. Antimicrobial Agents and Chemotherapy. 56(7): 3758-3766.

Wang J#, Wang W#, Wang L, Zhang G, Fan K, Tan H, Yang K (2011). A novel role of 'pseudo'γ-butyrolactone receptors in controlling γ-butyrolactone biosynthesis in Streptomyces. Mol Microbiol. 82(1):236-50

Pan Y, Wang L, He X, Tian Y, Liu G, and Tan H (2011). SabR enhances nikkomycin production via regulating the transcriptional level of sanG, a pathway-specific regulatory gene in Streptomyces ansochromogenes. BMC Microbiol. 20;11:164.

Wang L and Lin X (2011). Mechanisms of same sex mating in Cryptococcus neoformans. Fungal Genetics and Biology. 48:651–660.

Xu G, Wang J, Wang L, Tian X, Yang H, Fan K, Yang K, and Tan H (2010). 'Pseudo' gamma-butyrolactone receptors respond to antibiotic signals to coordinate antibiotics biosynthesis. J Biol Chem. 285(35):27440-8.

Yang H, An Y, Wang L, Zhang S, Zhang Y, Tian Y, Liu G and Tan H (2010). Autoregulation of hpdR and its effect on CDA biosynthesis in Streptomyces coelicolor. Microbiology. 156 (Pt 9):2641-8.

Wang L#, Tian X#, Wang J, Yang H, Fan K, Xu G, Yang K*, and Tan H*. (2009) Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator.PNAS 106 (21): 8617-22. (Evaluated in Faculty of 1000 Biology)

Wang L, Tan H. (2009) Molecular regulation of microbial secondary metabolites. Acta Microbiologica Sinica. 49(4): 411-416. (Mini-Review)

Zhang Y, Wang L, Zhang S, Yang H, Tan H. (2008) hmgA, transcriptionally activated by HpdA, influences the biosynthesis of actinorhodin in Streptomyces coelicolor. FEMS Microbiol Lett. 280(2): 219-215.

Yang H#, Wang L#, Xie Z, Tian Y, Liu G, Tan H*. (2007) The tyrosine degradation gene hppD is transcriptionally activated by HpdA and repressed by HpdR in Streptomyces coelicolor, while hpdA is negatively autoregulated and repressed by HpdR. Mol. Microbiol. 65 (4): 1064-1077