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Seminar: Carolyn Cannon, “Wolves in sheep clothing: Killing bacterial pathogens with innocuous compounds.”
October 31 @ 4:00 pm - 5:00 pm
Title: “Wolves in sheep clothing: Killing bacterial pathogens with innocuous compounds.”
Abstract: Combating the escalating problem of infections caused by multi-drug resistant (MDR) bacteria requires novel strategies. To treat lung infections caused by MDR pathogens, including methicillin resistant Staphylococcus aureus (MRSA) and MDR Pseudomonas aeruginosa, we aim to develop antimicrobial formulations including nanoparticle devices for pulmonary delivery. To that end, we have screened a library of compounds based on a natural product with excellent in vitro antimicrobial efficacy against MRSA. The activity of these compounds against MRSA in multiple growth modes in comparison to that of standard of care (SoC) antibiotics will be explored. Similarly, we have screened a library of silver carbene complexes (SCCs) utilizing a novel in vitro screening tool, which correlates highly with in vivo efficacy of the SCCs in a mouse model of P. aeruginosa pneumonia. Nanoparticle delivery of silver-based antimicrobials and enhancement of the antimicrobial activity of silver by ibuprofen will be discussed.
Host: Richard Gomer