Joined the Department in 2010
- B.A., 1977, Pomona College, Physics.
- Ph.D., 1983, Caltech, Biology.
- Postdoctoral research, University of California, San Diego.
- Previous faculty appointments: Rice University, Baylor College of Medicine, Howard Hughes Medical Institute.
Tissue size regulation, tissue cell composition, and fibrosing diseases
Our laboratory is working on three areas of biomedicine, trying to move observations from basic research into the clinic. First, we are studying how the sizes of tissues and tumors are regulated, and how this can be manipulated for therapeutic purposes. As a model system, we are using the simple eukaryote Dictyostelium discoideum, which allows us to combine techniques such as biochemistry, genetics, computer modeling, and cell biology to study tissue size regulation. We have found that a secreted protein as well as the unusual molecule polyphosphate are signals in negative feedback loops that inhibit Dictyostelium cell proliferation, and we are studying the signal transduction pathway to understand similar mechanisms in humans.
Second, we are studying how some secreted proteins can make cells move away from the source of the signal. We found such a signal (called a chemorepellent) in Dictyostelium, and then found a similar signal in humans. We are working to understand the signal transduction pathway for both. The human signal repels neutrophils, and we found that this can be used therapeutically in mouse models of neutrophil-driven diseases such as rheumatoid arthritis and acute respiratory distress syndrome.
Third, we have found that a human blood protein called Serum Amyloid P (SAP) regulates a key step in the formation of scar tissue as well as the formation of the scar-like lesions in fibrosing diseases such as congestive heart failure and pulmonary fibrosis. We are studying this mechanism, and a biotech company (Promedior) we co-founded is testing SAP as a therapy for fibrosis in patients in two Phase 2 trials.
- Karhadkar, TR, Pilling, D, Cox, N, Gomer, RH. Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model. Sci Rep. 2017;7 (1):15069. doi: 10.1038/s41598-017-15198-8. PubMed PMID:29118338 PubMed Central PMC5678159.
- Xiang, W, Cox, N, Gomer, RH. Identification of compounds that decrease numbers of Mycobacteria in human macrophages in the presence of serum amyloid P. J. Leukoc. Biol. 2017;102 (3):857-869. doi: 10.1189/jlb.1A0317-118RR. PubMed PMID:28768708 .
- Pilling, D, Galvis-Carvajal, E, Karhadkar, TR, Cox, N, Gomer, RH. Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands. BMC Immunol. 2017;18 (1):30. doi: 10.1186/s12865-017-0214-z. PubMed PMID:28619036 PubMed Central PMC5472910.
- Suess, PM, Watson, J, Chen, W, Gomer, RH. Extracellular polyphosphate signals through Ras and Akt to prime Dictyostelium discoideum cells for development. J. Cell. Sci. 2017;130 (14):2394-2404. doi: 10.1242/jcs.203372. PubMed PMID:28584190 PubMed Central PMC5536921.
- Herlihy, SE, Tang, Y, Phillips, JE, Gomer, RH. Functional similarities between the dictyostelium protein AprA and the human protein dipeptidyl-peptidase IV. Protein Sci. 2017;26 (3):578-585. doi: 10.1002/pro.3107. PubMed PMID:28028841 PubMed Central PMC5326566.
- Phillips, JE, Gomer, RH. A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases. Ann Transl Med. 2016;4 (Suppl 1):S20. doi: 10.21037/atm.2016.10.16. PubMed PMID:27867988 PubMed Central PMC5104632.
- Abeydeera, ND, Egli, M, Cox, N, Mercier, K, Conde, JN, Pallan, PS et al.. Evoking picomolar binding in RNA by a single phosphorodithioate linkage. Nucleic Acids Res. 2016;44 (17):8052-64. doi: 10.1093/nar/gkw725. PubMed PMID:27566147 PubMed Central PMC5041495.
- Suess, PM, Gomer, RH. Extracellular Polyphosphate Inhibits Proliferation in an Autocrine Negative Feedback Loop in Dictyostelium discoideum. J. Biol. Chem. 2016;291 (38):20260-9. doi: 10.1074/jbc.M116.737825. PubMed PMID:27519410 PubMed Central PMC5025707.
- Herlihy, SE, Starke, HE, Lopez-Anton, M, Cox, N, Keyhanian, K, Fraser, DJ et al.. Peritoneal Dialysis Fluid and Some of Its Components Potentiate Fibrocyte Differentiation. Perit Dial Int. ;36 (4):367-73. doi: 10.3747/pdi.2014.00284. PubMed PMID:26493752 PubMed Central PMC4934428.
- White, MJ, Gomer, RH. Trypsin, Tryptase, and Thrombin Polarize Macrophages towards a Pro-Fibrotic M2a Phenotype. PLoS ONE. 2015;10 (9):e0138748. doi: 10.1371/journal.pone.0138748. PubMed PMID:26407067 PubMed Central PMC4583378.