Joined the Department in 2010
- B.A., 1977, Pomona College, Physics.
- Ph.D., 1983, Caltech, Biology.
- Postdoctoral research, University of California, San Diego.
- Previous faculty appointments: Rice University, Baylor College of Medicine, Howard Hughes Medical Institute.
Tissue size regulation, tissue cell composition, and fibrosing diseases
Our laboratory is working on three areas of biomedicine, trying to move observations from basic research into the clinic. First, we are studying how the sizes of tissues and tumors are regulated, and how this can be manipulated for therapeutic purposes. As a model system, we are using the simple eukaryote Dictyostelium discoideum, which allows us to combine techniques such as biochemistry, genetics, computer modeling, and cell biology to study tissue size regulation. We have found that a secreted protein as well as the unusual molecule polyphosphate are signals in negative feedback loops that inhibit Dictyostelium cell proliferation, and we are studying the signal transduction pathway to understand similar mechanisms in humans.
Second, we are studying how some secreted proteins can make cells move away from the source of the signal. We found such a signal (called a chemorepellent) in Dictyostelium, and then found a similar signal in humans. We are working to understand the signal transduction pathway for both. The human signal repels neutrophils, and we found that this can be used therapeutically in mouse models of neutrophil-driven diseases such as rheumatoid arthritis and acute respiratory distress syndrome.
Third, we have found that a human blood protein called Serum Amyloid P (SAP) regulates a key step in the formation of scar tissue as well as the formation of the scar-like lesions in fibrosing diseases such as congestive heart failure and pulmonary fibrosis. We are studying this mechanism, and a biotech company (Promedior) we co-founded is testing SAP as a therapy for fibrosis in patients in two Phase 2 trials.
- Pilling, D, Chinea, LE, Consalvo, KM, Gomer, RH. Different Isoforms of the Neuronal Guidance Molecule Slit2 Directly Cause Chemoattraction or Chemorepulsion of Human Neutrophils. J. Immunol. 2018; :. doi: 10.4049/jimmunol.1800681. PubMed PMID:30510066 .
- Rijal, R, Consalvo, KM, Lindsey, CK, Gomer, RH. An endogenous chemorepellent directs cell movement by inhibiting pseudopods at one side of cells. Mol. Biol. Cell. 2018; :mbcE18090562. doi: 10.1091/mbc.E18-09-0562. PubMed PMID:30462573 .
- Pilling, D, Gomer, RH. The Development of Serum Amyloid P as a Possible Therapeutic. Front Immunol. 2018;9 :2328. doi: 10.3389/fimmu.2018.02328. PubMed PMID:30459752 PubMed Central PMC6232687.
- Tang, Y, Wu, Y, Herlihy, SE, Brito-Aleman, FJ, Ting, JH, Janetopoulos, C et al.. An Autocrine Proliferation Repressor Regulates Dictyostelium discoideum Proliferation and Chemorepulsion Using the G Protein-Coupled Receptor GrlH. MBio. 2018;9 (1):. doi: 10.1128/mBio.02443-17. PubMed PMID:29440579 PubMed Central PMC5821085.
- White, MJV, Chinea, LE, Pilling, D, Gomer, RH. Protease activated-receptor 2 is necessary for neutrophil chemorepulsion induced by trypsin, tryptase, or dipeptidyl peptidase IV. J. Leukoc. Biol. 2018;103 (1):119-128. doi: 10.1002/JLB.3A0717-308R. PubMed PMID:29345066 .
- Chen, W, Pilling, D, Gomer, RH. Dietary NaCl affects bleomycin-induced lung fibrosis in mice. Exp. Lung Res. ;43 (9-10):395-406. doi: 10.1080/01902148.2017.1385110. PubMed PMID:29220597 PubMed Central PMC6004787.
- Chen, W, Pilling, D, Gomer, RH. C-reactive protein (CRP) but not the related pentraxins serum amyloid P and PTX3 inhibits the proliferation and induces apoptosis of the leukemia cell line Mono Mac 6. BMC Immunol. 2017;18 (1):47. doi: 10.1186/s12865-017-0230-z. PubMed PMID:29202702 PubMed Central PMC5716379.
- Karhadkar, TR, Pilling, D, Cox, N, Gomer, RH. Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model. Sci Rep. 2017;7 (1):15069. doi: 10.1038/s41598-017-15198-8. PubMed PMID:29118338 PubMed Central PMC5678159.
- Xiang, W, Cox, N, Gomer, RH. Identification of compounds that decrease numbers of Mycobacteria in human macrophages in the presence of serum amyloid P. J. Leukoc. Biol. 2017;102 (3):857-869. doi: 10.1189/jlb.1A0317-118RR. PubMed PMID:28768708 .
- Pilling, D, Galvis-Carvajal, E, Karhadkar, TR, Cox, N, Gomer, RH. Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands. BMC Immunol. 2017;18 (1):30. doi: 10.1186/s12865-017-0214-z. PubMed PMID:28619036 PubMed Central PMC5472910.