Faculty: Arne Lekven 2017-09-01T10:00:14+00:00
Arne Lekven

Arne Lekven

Professor

Fax: 979-845-2891
Email: alekven@bio.tamu.edu

Curriculum Vitae
Lekven Lab Website

Office:
3258 TAMU
Biological Sciences Building East
Room 118B
979-458-3461

Lab:
Biological Sciences Building East
Room 108
979-845-7784

Joined the Department in 2001

  • B.A., 1989, UC San Diego, Animal Physiology.
  • Ph.D., 1997, UCLA, Molecular, Cell and Developmental Biology
  • Postdoctoral Research, University of Washington School of Medicine, Department of Pharmacology, Developmental Biology.

Our lab uses the zebrafish as a model organism to understand the link between cell signaling and embryonic patterning and tissue growth.  More specifically, we are dissecting how the Wnt signal transduction pathway regulates ventrolateral mesoderm and midbrain/hindbrain patterning and growth. Our projects use an array of molecular genetic methods to study the regulation and output of Wnt8a signaling and how it affects mesoderm and brain development, the timing of Wnt regulation of brain patterning and the downstream genes that mediate Wnt pathway effects.

  1. Kunkel, GR, Tracy, JA, Jalufka, FL, Lekven, AC. CHD8short, a naturally-occurring truncated form of a chromatin remodeler lacking the helicase domain, is a potent transcriptional coregulator. Gene. 2018;641 :303-309. doi: 10.1016/j.gene.2017.10.058. PubMed PMID:29079199 .
  2. Gibbs, HC, Chang-Gonzalez, A, Hwang, W, Yeh, AT, Lekven, AC. Midbrain-Hindbrain Boundary Morphogenesis: At the Intersection of Wnt and Fgf Signaling. Front Neuroanat. 2017;11 :64. doi: 10.3389/fnana.2017.00064. PubMed PMID:28824384 PubMed Central PMC5541008.
  3. Gibbs, HC, Dodson, CR, Bai, Y, Lekven, AC, Yeh, AT. Combined lineage mapping and gene expression profiling of embryonic brain patterning using ultrashort pulse microscopy and image registration. J Biomed Opt. 2014;19 (12):126016. doi: 10.1117/1.JBO.19.12.126016. PubMed PMID:25539062 .
  4. Green, D, Whitener, AE, Mohanty, S, Lekven, AC. Vertebrate nervous system posteriorization: Grading the function of Wnt signaling. Dev. Dyn. 2015;244 (3):507-12. doi: 10.1002/dvdy.24230. PubMed PMID:25410702 .
  5. Wylie, AD, Fleming, JA, Whitener, AE, Lekven, AC. Post-transcriptional regulation of wnt8a is essential to zebrafish axis development. Dev. Biol. 2014;386 (1):53-63. doi: 10.1016/j.ydbio.2013.12.003. PubMed PMID:24333179 .
  6. Narayanan, A, Lekven, AC. Biphasic wnt8a expression is achieved through interactions of multiple regulatory inputs. Dev. Dyn. 2012;241 (6):1062-75. doi: 10.1002/dvdy.23787. PubMed PMID:22473868 .
  7. Halbig, KM, Lekven, AC, Kunkel, GR. The transcriptional activator ZNF143 is essential for normal development in zebrafish. BMC Mol. Biol. 2012;13 :3. doi: 10.1186/1471-2199-13-3. PubMed PMID:22268977 PubMed Central PMC3282657.
  8. Narayanan, A, Thompson, SA, Lee, JJ, Lekven, AC. A transgenic wnt8a:PAC reporter reveals biphasic regulation of vertebrate mesoderm development. Dev. Dyn. 2011;240 (4):898-907. doi: 10.1002/dvdy.22599. PubMed PMID:21384472 .
  9. Baker, KD, Ramel, MC, Lekven, AC. A direct role for Wnt8 in ventrolateral mesoderm patterning. Dev. Dyn. 2010;239 (11):2828-36. doi: 10.1002/dvdy.22419. PubMed PMID:20845427 .
  10. Halbig, KM, Lekven, AC, Kunkel, GR. Zebrafish U6 small nuclear RNA gene promoters contain a SPH element in an unusual location. Gene. 2008;421 (1-2):89-94. doi: 10.1016/j.gene.2008.06.019. PubMed PMID:18619527 .
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