• B.S., 2001, Purdue University, Biochemistry.
  • Ph.D., 2006, The University of Chicago, Microbiology.
  • Postdoctoral research: Tufts University School of Medicine.

Joined the department in 2010.

Sorg Lab Website

Research Description

My lab is focused on the mechanisms of spore germination and bile acid resistance in Clostridium difficileC. difficile is a Gram-positive, spore forming, anaerobe that causes infections in people who have undergone antibiotic regimens.  Previously, we had shown that certain bile acids promote C. difficile spore germination while others inhibit germination.  Bile acids are small molecules made by the liver that help the absorption of fat and cholesterol in the GI tract while also serving as a protective barrier against invading pathogens.  Because C. difficile spores use the ratios of bile acids as cues for germination, the actively growing bacteria must have adapted means to avoid their toxic properties.  We are currently focused on identifying these factors and the mechanisms by which C. difficile spores germinate.

Search PubMed
Joseph Sorg

Joseph Sorg
Associate Professor

3258 TAMU
College Station, TX 77843-3258

Office:
Biological Sciences Building East
Room 314C
979-845-6299

Lab:
Biological Sciences Building East
Room 316
979-845-6233
Fax: 979-845-2891
Email: jsorg@bio.tamu.edu

Curriculum Vitae