Lockless Lab

Research Interests

Electrical and motile properties of microorganisms

  • Physiological role of microbial cation channels
  • Membrane potential modulation by small molecules and proteins
  • Connection between motility, stress response and cell division

Information content within microbial and human genome sequences

  • Extraction of useful information from whole genome sequencing
  • Whole genome coevolution to predict connections between proteins
  • Development of tools to analyze circular genomes

Associate Professor
lockless@bio.tamu.edu

Department of Biology
TAMU 3474
College Station, TX 77843

Office: 3474 TAMU
Interdisciplinary Life Sciences Building
Room 3141B
979-845-9824
Fax: 979-845-2891

Lab: Interdisciplinary Life Sciences Building
Room 3132A

Lab Members

Steve Lockless, Principle Investigator
Associate Professor, Department of Biology
Faculty of Neuroscience & Faculty of Ecology and Evolutionary Biology
Ph.D., Molecular Biophysics, University of Texas Southwestern Medical Center
B.S., Molecular & Cellular Biology, Texas A&M University
lockless@bio.tamu.edu
ILSB 3141B
979.845.9824

Sarah Beagle,
Ph.D. Student
B.S., Biology, Washburn University
sbeagle@bio.tamu.edu

Jibran Khan,
Ph.D. Student (co-advised with Dr. Katy Kao, Chem. Eng.)
M.S., Biotechnology, University of Texas at San Antonio
B.S., Biotechnology, University of Pune, India
jkhan@bio.tamu.edu

Katrina Hofstetter,
Ph.D. Student
M.S., Biology, Idaho State University
B.S., Biology, Idaho State University
hofskatr@tamu.edu

Ashley Hudson,
Ph.D. Student
B.S., Biology, St. Edward’s University
mhudson@bio.tamu.edu

Hannah Gooden,
Undergraduate, Computer Science Major

Cierra Weathers,
Undergraduate, Microbiology Major

Rebekah Redmond,
Undergraduate, Microbiology Major

Lockless Lab Alumni (in order of joining the laboratory):

Ashwathi Mohan
Taylor Ryan
Shian Liu, Ph.D.
Xuelin Bian, Ph.D.
Austin Jones
Joshua Cadungog
Morgan Hatfield
Joel Oliver
Michael Brooks
Brooke Versaw
Fernanda Gutierrez
Madeline Smoot
Samuel Erickson
Greg Whitaker
Ryan Fields
Rachel Porter
Teresa Kenny

Biol 213 – Molecular Cell Biology

The purpose of this course is to provide a rigorous foundation in current molecular and cellular biology. This material is the basis for much of current medical practices, many areas of science, and is having a major impact on ethical issues in society.  In addition, many of the upper level life science courses will begin by assuming that you know this material.

Learning Objectives:

(1) Describe the structures, molecules and mechanisms of cellular energy generation and management, (2) Describe the processes of cellular endomembrane sorting and transport among different organelles in the cytoplasm, (3) Describe the molecular components and mechanisms of cellular signal transduction, (4) Describe the structures, functions, and the molecular components of the cytoskeleton, (5) Describe the molecular nature of the gene and its expression contributing to the cellular phenotype, and (6) Describe the processes, stages, and regulation of cell mitosis and division.


Biol 651 – Bioinformatics

The growing information in biological systems will impact the research direction in many diverse fields. This course is designed to introduce graduate students to the principles of bioinformatics, including both theoretical and practical aspects. Students will learn how to manipulate biologically relevant datasets including protein sequences, protein structures and nucleic acid sequences (both DNA and RNA), as well as build a foundation to analyze types of datasets that do not yet exist.  There are no prerequisites for this course but a basic understanding of molecular biology including the central dogma and a positive attitude towards computers are helpful.

Learning Objectives:

(1) Quantify correlations in data using different approaches to identify functionally relevant parameters, (2) Create protein sequence alignment and identify conserved positions, (3) Download, manipulate and display the 3-D structure of a protein, (4) Describe the constraints evolution imposes on a protein’s structure/function, (5) Explain the differences between traditional and Next Generation Sequencing (NGS), (6) Design experiments using NGS to address cellular biology questions, and (7) Discuss the different types of information that can be extracted from genome sequences.