Joined the Department in 2015
- B.S., 2002 College of Life Sciences, Inner Mongolia University, China, Microbiology
- Ph.D., 2007 College of Life Sciences, Peking University, China, Biochemistry and Molecular Biology.
- Postdoctoral research, University of California, Berkeley
Editor of Frontiers in Microbiology
Member of the American Society of Microbiology
I am interested in understanding the mechanisms of fundamental biological processes in bacteria. My lab uses soil bacterium Myxococcus xanthus as the model organism. Several aspects of M. xanthus make it an ideal model for understanding bacterial physiology. First, M. xanthus cells utilize sophisticated systems to move on solid surfaces, which involve cytoplasmic and periplasmic proteins, filamentous cytoskeletons, membrane channels, cell wall, and cell surface components. Second, cells constantly communicate with each other and with their environment. Cells usually move in coordinated groups but also as isolated “adventurous” individuals, which allows this bacterium to feed on soil detritus and prey on other microorganisms. Third, when the availability of nutrients or prey decrease in the environment, most cells exhibit behaviors that include aggregation into fruiting bodies and conversion of individual cells into spores.
I have been using the super resolution photo-activated localization microscopy (PALM) to track single molecule dynamics of proteins in live bacterial cells. With this technique, I have achieved 10 millisecond time resolution (100 frames per second) and 80 nm spatial resolution. These studies were initiated because the most widely used fluorescence microscopy techniques (including confocal, deconvolution, etc.) can only provide resolution to about 200 nm due to the diffraction of light, which is often insufficient for many studies because of the small size of bacterial cells (usually a few hundred nanometers in diameter).
Our research topics cover motility, development (fruiting body formation and biofilm formation), cytoskeleton, and cell wall assembly.
- Fang, Y, Lian, X, Huang, Y, Fu, G, Xiao, Z, Wang, Q et al.. Investigating Subcellular Compartment Targeting Effect of Porous Coordination Cages for Enhancing Cancer Nanotherapy. Small. 2018;14 (47):e1802709. doi: 10.1002/smll.201802709. PubMed PMID:30222252 PubMed Central PMC6563816.
- Fu, G, Bandaria, JN, Le Gall, AV, Fan, X, Yildiz, A, Mignot, T et al.. MotAB-like machinery drives the movement of MreB filaments during bacterial gliding motility. Proc. Natl. Acad. Sci. U.S.A. 2018;115 (10):2484-2489. doi: 10.1073/pnas.1716441115. PubMed PMID:29463706 PubMed Central PMC5877941.
- Pogue, CB, Zhou, T, Nan, B. PlpA, a PilZ-like protein, regulates directed motility of the bacterium Myxococcus xanthus. Mol. Microbiol. 2018;107 (2):214-228. doi: 10.1111/mmi.13878. PubMed PMID:29127741 .
- Nan, B. Bacterial Gliding Motility: Rolling Out a Consensus Model. Curr. Biol. 2017;27 (4):R154-R156. doi: 10.1016/j.cub.2016.12.035. PubMed PMID:28222296 .
- Jiang, X, Hernandez, D, Hernandez, C, Ding, Z, Nan, B, Aufderheide, K et al.. IFT57 stabilizes the assembled intraflagellar transport complex and mediates transport of motility-related flagellar cargo. J. Cell. Sci. 2017;130 (5):879-891. doi: 10.1242/jcs.199117. PubMed PMID:28104816 .
- Zhou, T, Nan, B. Exopolysaccharides promote Myxococcus xanthus social motility by inhibiting cellular reversals. Mol. Microbiol. 2017;103 (4):729-743. doi: 10.1111/mmi.13585. PubMed PMID:27874229 .
- Nan, B, Zusman, DR. Novel mechanisms power bacterial gliding motility. Mol. Microbiol. 2016;101 (2):186-93. doi: 10.1111/mmi.13389. PubMed PMID:27028358 PubMed Central PMC5008027.
- Hallberg, ZF, Wang, XC, Wright, TA, Nan, B, Ad, O, Yeo, J et al.. Hybrid promiscuous (Hypr) GGDEF enzymes produce cyclic AMP-GMP (3', 3'-cGAMP). Proc. Natl. Acad. Sci. U.S.A. 2016;113 (7):1790-5. doi: 10.1073/pnas.1515287113. PubMed PMID:26839412 PubMed Central PMC4763787.