Discovery and Characterization of Novel Antimicrobial Agents
The discovery of novel antimicrobials and the study of antimicrobial function have significant relevance towards the development of therapeutics aimed at treating life threatening diseases. However, much of what we have learned about protein synthesis, DNA replication, enzyme function, as well as membrane physiology comes from the study of antimicrobials. Our knowledge of cellular and membrane physiology is still limited and there is much we need to learn. The discovery and structural and functional characterization of new antimicrobial agents will provide new insights into cellular and membrane function, as well as provide means to intellectually design new analogs that target microbial function. The discovery of new enzymes involved in natural product synthesis also provides invaluable information in understanding the complexity of microorganisms and provides tools for synthetic chemistry applications.
Cothrell, A, Cao, K, Bonasera, R, Tenorio, A, Orugunty, R, Smith, L et al.. Intravaginal Gel for Sustained Delivery of Occidiofungin and Long-Lasting Antifungal Effects. Gels. 2023;9 (10):. doi: 10.3390/gels9100787. PubMed PMID:37888361 PubMed Central PMC10606712.
Barbour, A, Smith, L, Oveisi, M, Williams, M, Huang, RC, Marks, C et al.. Discovery of phosphorylated lantibiotics with proimmune activity that regulate the oral microbiome. Proc Natl Acad Sci U S A. 2023;120 (22):e2219392120. doi: 10.1073/pnas.2219392120. PubMed PMID:37216534 PubMed Central PMC10235938.
Ju, M, Joseph, T, Hansanant, N, Geng, M, Williams, M, Cothrell, A et al.. Evaluation of analogs of mutacin 1140 in systemic and cutaneous methicillin-resistant Staphylococcus aureus infection models in mice. Front Microbiol. 2022;13 :1067410. doi: 10.3389/fmicb.2022.1067410. PubMed PMID:36590413 PubMed Central PMC9794991.
Geng, M, Hansanant, N, Lu, SE, Lockless, SW, Shin, R, Orugunty, R et al.. Synthesis and characterization of semisynthetic analogs of the antifungal occidiofungin. Front Microbiol. 2022;13 :1056453. doi: 10.3389/fmicb.2022.1056453. PubMed PMID:36583054 PubMed Central PMC9792986.
Ravichandran, A, Escano, J, Lee, JH, Ross, MK, Austin, F, Orugunty, R et al.. Formulation, Pharmacological Evaluation, and Efficacy Studies of Occidiofungin, a Novel Antifungal. Antimicrob Agents Chemother. 2020;64 (12):. doi: 10.1128/AAC.01737-20. PubMed PMID:32958713 PubMed Central PMC7674058.
Barbour, A, Wescombe, P, Smith, L. Evolution of Lantibiotic Salivaricins: New Weapons to Fight Infectious Diseases. Trends Microbiol. 2020;28 (7):578-593. doi: 10.1016/j.tim.2020.03.001. PubMed PMID:32544444 .
Ma, J, Guo, F, Jin, Z, Geng, M, Ju, M, Ravichandran, A et al.. Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin. Antimicrob Agents Chemother. 2020;64 (8):. doi: 10.1128/AAC.00244-20. PubMed PMID:32457108 PubMed Central PMC7526809.