Manfred Schartl

Visiting Professor
Hagler Institute for Advanced Study

Fax: 979-845-2891
Email:
phch1@biozentrum.uni-wuerzburg.de

Curriculum Vitae
HIAS Profile

Office:
3258 TAMU
Butler Hall
Room 306A

Lab:
Butler Hall
Room 306

Joined the Department in 2016

  • Dipl. Biol, 1978, University of Gießen (Gießen, Germany), Studies in Biology
  • Teaching Certificate, 1979, University of Gießen (Gießen, Germany), Biology and Chemistry
  • Dr. rer. nat., 1980, University of Gießen (Gießen, Germany), Genetics
  • Habilitation, 1988, Ludwig-Maximilian-University (Munich, Germany), Faculty of Biology

My main research interests are molecular processes in organismic development and their malfunction in cancerogenesis.

One major topic of my laboratory is the understanding of signal transduction and gene regulation in cancer, in particular melanoma. Malignant melanoma is one of the most dangerous tumors with an incidence rising faster than any type of cancer worldwide. We use the classical Xiphophorus model system and transgenic medaka that develop different types of pigment cell tumors. With the established tools of biochemistry and molecular genetics as well as high throughput and deep sequencing methods (RNA-seq, CHiP-seq, RAD-tags) we want to better understand the molecular mechanisms that make a normal pigment cell turn into a malignant cancer cells and provide on this basis novel approaches for better diagnoses and therapies.

A second major interest is in the molecular basis and evolution of sex determination. Sex can be determined by a plethora of mechanisms and the different mechanisms do not follow a phylogenetic pattern. Particularly in fish, sex determination is highly variable, sometimes even among closely related species. We want to understand the reasons why this variability exists and what molecular changes are involved. We use a comparative approach studying various fish species. This includes developmental biological studies on the processes that make the decision in the embryo or larvae if the undifferentiated bipotential gonad will develop either as testis or ovary laboratory model fish species. Besides we try to identify the unknown sex determination genes from fish that are representing major branches of the fish tree of life and are of interest because of special ecological, evolutionary or economic features.

Because the function of any gene is shaped by its evolutionary history and its genomic context we are interested in the evolution of genes involved in cancer, pigmentation, sex determination and reproductive development. The opportunities offered by the next generation sequencing technologies allow to obtain the full genome information now also for interesting species besides the mainstream laboratory models, which offers new insights into their evolution and biology.

We are members of several international consortia (some initiated and coordinated by us) for the de-novo sequencing, assembly and annotation of fish genomes, which include our melanoma model organism, the platyfish Xiphophorus maculatus, the Amazon molly, a unisexual clonal fish species, two marine flatfish, two cyprinid species, the coelacanth Latimeria chalumnae, the lungfish and several others. We analyze the genomes with a special attention to the evolution of genes and gene families, which are of our interest from the cancer projects and the evolution of sex determination mechanisms and sex chromosomes. Major focuses are gene and whole genome duplications as important drivers of evolutionary innovations and adaptations. We are also interested how several traits like secondary sex characters, the age of sexual maturation (puberty) or pigmentation patterns evolve and have an impact on speciation.

  1. Etheredge, RI, Schartl, M, Jordan, A. Decontextualized learning for interpretable hierarchical representations of visual patterns. Patterns (N Y). 2021;2 (2):100193. doi: 10.1016/j.patter.2020.100193. PubMed PMID:33659910 PubMed Central PMC7892362.
  2. Feron, R, Pan, Q, Wen, M, Imarazene, B, Jouanno, E, Anderson, J et al.. RADSex: a computational workflow to study sex determination using Restriction Site-Associated DNA Sequencing data. Mol Ecol Resour. 2021; :. doi: 10.1111/1755-0998.13360. PubMed PMID:33590960 .
  3. Lu, Y, Bierbach, D, Ormanns, J, Warren, WC, Walter, RB, Schartl, M et al.. Fixation of allelic gene expression landscapes and expression bias pattern shape the transcriptome of the clonal Amazon molly. Genome Res. 2021;31 (3):372-379. doi: 10.1101/gr.268870.120. PubMed PMID:33547183 .
  4. Adolfi, MC, Herpin, A, Martinez-Bengochea, A, Kneitz, S, Regensburger, M, Grunwald, DJ et al.. Crosstalk Between Retinoic Acid and Sex-Related Genes Controls Germ Cell Fate and Gametogenesis in Medaka. Front Cell Dev Biol. 2020;8 :613497. doi: 10.3389/fcell.2020.613497. PubMed PMID:33537305 PubMed Central PMC7848095.
  5. Pan, Q, Feron, R, Jouanno, E, Darras, H, Herpin, A, Koop, B et al.. The rise and fall of the ancient northern pike master sex-determining gene. Elife. 2021;10 :. doi: 10.7554/eLife.62858. PubMed PMID:33506762 PubMed Central PMC7870143.
  6. Meyer, A, Schloissnig, S, Franchini, P, Du, K, Woltering, JM, Irisarri, I et al.. Giant lungfish genome elucidates the conquest of land by vertebrates. Nature. 2021;590 (7845):284-289. doi: 10.1038/s41586-021-03198-8. PubMed PMID:33461212 PubMed Central PMC7875771.
  7. Fofanov, MV, Prokopov, DY, Kuhl, H, Schartl, M, Trifonov, VA. Evolution of MicroRNA Biogenesis Genes in the Sterlet (Acipenser ruthenus) and Other Polyploid Vertebrates. Int J Mol Sci. 2020;21 (24):. doi: 10.3390/ijms21249562. PubMed PMID:33334059 PubMed Central PMC7765534.
  8. Schartl, M, Kneitz, S, Ormanns, J, Schmidt, C, Anderson, JL, Amores, A et al.. The Developmental and Genetic Architecture of the Sexually Selected Male Ornament of Swordtails. Curr Biol. 2020; :. doi: 10.1016/j.cub.2020.11.028. PubMed PMID:33275891 .
  9. Biltueva, LS, Prokopov, DY, Romanenko, SA, Interesova, EA, Schartl, M, Trifonov, VA et al.. Chromosome Distribution of Highly Conserved Tandemly Arranged Repetitive DNAs in the Siberian Sturgeon (Acipenser baerii). Genes (Basel). 2020;11 (11):. doi: 10.3390/genes11111375. PubMed PMID:33233736 PubMed Central PMC7699875.
  10. Phan, QT, Liu, R, Tan, WH, Imangali, N, Cheong, B, Schartl, M et al.. Macrophages Switch to an Osteo-Modulatory Profile Upon RANKL Induction in a Medaka (Oryzias latipes) Osteoporosis Model. JBMR Plus. 2020;4 (11):e10409. doi: 10.1002/jbm4.10409. PubMed PMID:33210062 PubMed Central PMC7657398.
Search PubMed