photo of matthias koch
Matthias Koch

Assistant Professor

Koch Lab Website

Fax: 979-845-2891


409 BSBW


401 BSBW

Joined the Department in 2022

  • M.Sc., Physics, University of Freiburg. 2010
  • Ph.D., Biophysics. 2015
  • Postdoctoral research, Princeton University. 2015-2022
  1. Padron, GC, Shuppara, AM, Sharma, A, Koch, MD, Palalay, JS, Radin, JN et al.. Shear rate sensitizes bacterial pathogens to H2O2 stress. Proc Natl Acad Sci U S A. 2023;120 (11):e2216774120. doi: 10.1073/pnas.2216774120. PubMed PMID:36888662 .
  2. Koch, MD, Shaevitz, JW. Art Ashkin and the Origins of Optical Trapping and Particle Manipulation. Methods Mol Biol. 2022;2478 :11-22. doi: 10.1007/978-1-0716-2229-2_2. PubMed PMID:36063316 .
  3. Koch, MD, Black, ME, Han, E, Shaevitz, JW, Gitai, Z. Pseudomonas aeruginosa distinguishes surfaces by stiffness using retraction of type IV pili. Proc Natl Acad Sci U S A. 2022;119 (20):e2119434119. doi: 10.1073/pnas.2119434119. PubMed PMID:35561220 PubMed Central PMC9171759.
  4. Koch, MD, Fei, C, Wingreen, NS, Shaevitz, JW, Gitai, Z. Competitive binding of independent extension and retraction motors explains the quantitative dynamics of type IV pili. Proc Natl Acad Sci U S A. 2021;118 (8):. doi: 10.1073/pnas.2014926118. PubMed PMID:33593905 PubMed Central PMC7923367.
  5. Scheffler, RJ, Sugimoto, Y, Bratton, BP, Ellison, CK, Koch, MD, Donia, MS et al.. Pseudomonas aeruginosa detachment from surfaces via a self-made small molecule. J Biol Chem. 2021;296 :100279. doi: 10.1016/j.jbc.2021.100279. PubMed PMID:33450229 PubMed Central PMC7949062.
  6. Simsek, AN, Braeutigam, A, Koch, MD, Shaevitz, JW, Huang, Y, Gompper, G et al.. Substrate-rigidity dependent migration of an idealized twitching bacterium. Soft Matter. 2019;15 (30):6224-6236. doi: 10.1039/c9sm00541b. PubMed PMID:31334524 .
  7. Sanfilippo, JE, Lorestani, A, Koch, MD, Bratton, BP, Siryaporn, A, Stone, HA et al.. Microfluidic-based transcriptomics reveal force-independent bacterial rheosensing. Nat Microbiol. 2019;4 (8):1274-1281. doi: 10.1038/s41564-019-0455-0. PubMed PMID:31086313 PubMed Central PMC6656604.
  8. Roth, J, Koch, MD, Rohrbach, A. Dynamics of a Protein Chain Motor Driving Helical Bacteria under Stress. Biophys J. 2018;114 (8):1955-1969. doi: 10.1016/j.bpj.2018.02.043. PubMed PMID:29694872 PubMed Central PMC5937200.
  9. Koch, MD, Rohrbach, A. Label-free Imaging and Bending Analysis of Microtubules by ROCS Microscopy and Optical Trapping. Biophys J. 2018;114 (1):168-177. doi: 10.1016/j.bpj.2017.10.036. PubMed PMID:29320684 PubMed Central PMC5773756.
  10. Sabass, B, Koch, MD, Liu, G, Stone, HA, Shaevitz, JW. Force generation by groups of migrating bacteria. Proc Natl Acad Sci U S A. 2017;114 (28):7266-7271. doi: 10.1073/pnas.1621469114. PubMed PMID:28655845 PubMed Central PMC5514709.
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