photo of matthias koch
Matthias Koch

Assistant Professor

Koch Lab Website

Fax: 979-845-2891


409 BSBW


401 BSBW

Joined the Department in 2022

  • M.Sc., Physics, University of Freiburg. 2010
  • Ph.D., Biophysics. 2015
  • Postdoctoral research, Princeton University. 2015-2022
  1. Wang, B, Lin, AE, Yuan, J, Novak, KE, Koch, MD, Wingreen, NS et al.. Single-cell massively-parallel multiplexed microbial sequencing (M3-seq) identifies rare bacterial populations and profiles phage infection. Nat Microbiol. 2023;8 (10):1846-1862. doi: 10.1038/s41564-023-01462-3. PubMed PMID:37653008 PubMed Central PMC10522482.
  2. Han, E, Fei, C, Alert, R, Copenhagen, K, Koch, MD, Wingreen, NS et al.. Local polar order controls mechanical stress and triggers layer formation in developing Myxococcus xanthus colonies. ArXiv. 2023; :. . PubMed PMID:37576128 PubMed Central PMC10418523.
  3. Simsek, AN, Koch, MD, Sanfilippo, JE, Gitai, Z, Gompper, G, Sabass, B et al.. Type-IV pili tune an adhesion-migration trade-off during surface colonization of Pseudomonas aeruginosa. bioRxiv. 2023; :. doi: 10.1101/2023.05.09.538458. PubMed PMID:37215001 PubMed Central PMC10197611.
  4. Padron, GC, Shuppara, AM, Sharma, A, Koch, MD, Palalay, JS, Radin, JN et al.. Shear rate sensitizes bacterial pathogens to H2O2 stress. Proc Natl Acad Sci U S A. 2023;120 (11):e2216774120. doi: 10.1073/pnas.2216774120. PubMed PMID:36888662 PubMed Central PMC10089187.
  5. Koch, MD, Shaevitz, JW. Art Ashkin and the Origins of Optical Trapping and Particle Manipulation. Methods Mol Biol. 2022;2478 :11-22. doi: 10.1007/978-1-0716-2229-2_2. PubMed PMID:36063316 .
  6. Koch, MD, Black, ME, Han, E, Shaevitz, JW, Gitai, Z. Pseudomonas aeruginosa distinguishes surfaces by stiffness using retraction of type IV pili. Proc Natl Acad Sci U S A. 2022;119 (20):e2119434119. doi: 10.1073/pnas.2119434119. PubMed PMID:35561220 PubMed Central PMC9171759.
  7. Koch, MD, Fei, C, Wingreen, NS, Shaevitz, JW, Gitai, Z. Competitive binding of independent extension and retraction motors explains the quantitative dynamics of type IV pili. Proc Natl Acad Sci U S A. 2021;118 (8):. doi: 10.1073/pnas.2014926118. PubMed PMID:33593905 PubMed Central PMC7923367.
  8. Scheffler, RJ, Sugimoto, Y, Bratton, BP, Ellison, CK, Koch, MD, Donia, MS et al.. Pseudomonas aeruginosa detachment from surfaces via a self-made small molecule. J Biol Chem. 2021;296 :100279. doi: 10.1016/j.jbc.2021.100279. PubMed PMID:33450229 PubMed Central PMC7949062.
  9. Simsek, AN, Braeutigam, A, Koch, MD, Shaevitz, JW, Huang, Y, Gompper, G et al.. Substrate-rigidity dependent migration of an idealized twitching bacterium. Soft Matter. 2019;15 (30):6224-6236. doi: 10.1039/c9sm00541b. PubMed PMID:31334524 .
  10. Sanfilippo, JE, Lorestani, A, Koch, MD, Bratton, BP, Siryaporn, A, Stone, HA et al.. Microfluidic-based transcriptomics reveal force-independent bacterial rheosensing. Nat Microbiol. 2019;4 (8):1274-1281. doi: 10.1038/s41564-019-0455-0. PubMed PMID:31086313 PubMed Central PMC6656604.
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