Shogo Sato

Assistant Professor

Fax: 979-845-2891

3258 TAMU
Biological Sciences Building West
Room 309

Biological Sciences Building West
Room 309

Joined the Department in 2021

  • M.S. Human Sciences, Waseda University, Japan. 2009
  • Ph.D. Human Sciences, Waseda University, Japan. 2012
  • Adjunct Research Fellow, Kyorin University, Tokyo. 2012-2013
  • Research Fellow, JSPS, Tokyo. 2010
  • Postdoctoral Fellow UTSW Medical Center, Dallas. 2013-2015
  • Postdoctoral Fellow, University of California. 2015


Japanese Society for Chronobiology

The Physiological Society of Japan

American Heart Association

Japanese Society of Physiological Fitness and Sports Medicine

Postdoc Position Available

A broad range of physiological functions exhibits daily variations, such as the sleep/wake cycle, the endocrine system, and metabolism, which are precisely controlled by molecular circadian clocks. Importantly, genetic deletion of the circadian clock components results in robust phenotypes related to metabolic disorders and premature aging, while simultaneously the circadian clock functions are reprogrammed by metabolic and epigenetic modifications. Molecular insights of how the circadian clock affiliates with metabolism underscore the interaction between disrupted circadian clockwork, abnormal behavioral rhythms, and metabolic diseases. This points to a potential strategy for the promotion of metabolic health and the treatment of metabolic diseases through systemic and local activation of the circadian regulation of homeostasis. This notion is strongly supported by mounting evidence indicating that dietary intervention exerts beneficial impacts on the circadian core clock machinery and thus clock-controlled metabolic pathways. Undoubtedly, the prevention and treatment of metabolic diseases are placed as a crucial health problem.

Dr. Sato has a broad research background in circadian biology combined with growing knowledge in biochemistry, epigenetics, and metabolism. Especially during his second postdoctoral career in the laboratory of the late Paolo Sassone-Corsi at UCI, he has been tackling the question of how the circadian clock links to metabolic functions. Dr. Sato demonstrated the circadian control of metabolic pathways is reprogramed by aging, which is rescued by caloric restriction (Sato et al., Cell 2017). More recently, Dr. Sato investigated the time-dependent impact of exercise, revealing exercise at the early active phase (fasted phase) exerts robust metabolic responses in skeletal muscle (Sato et al., Cell Metab 2019) and illustrating the atlas of exercise metabolism unique to different exercise timing (Sato et al., Cell under revision). Lastly, Dr. Sato discovered a novel non-canonical role played by the circadian clock specific to pluripotent stem cells (Sato et al., in preparation). Taken together, his past/ongoing studies contribute to the accumulation of evidence underscoring a healthy lifestyle relied on biological clocks.

The goals of Sato lab will be to 1) achieve a fundamental understanding of the intertwined link between metabolism, epigenetics, and the circadian clock, and 2) establish translational interventions targeting the circadian clock system to promote human health by using molecular, biochemical, physiological, and bioinformatics approaches.

  1. Lundell, LS, Parr, EB, Devlin, BL, Ingerslev, LR, Altıntaş, A, Sato, S et al.. Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression. Nat Commun. 2020;11 (1):4643. doi: 10.1038/s41467-020-18412-w. PubMed PMID:32938935 PubMed Central PMC7495469.
  2. Sato, S, Bunney, BG, Vawter, MP, Bunney, WE, Sassone-Corsi, P. Homer1a Undergoes Bimodal Transcriptional Regulation by CREB and the Circadian Clock. Neuroscience. 2020;434 :161-170. doi: 10.1016/j.neuroscience.2020.03.031. PubMed PMID:32222559 .
  3. Sato, S, Basse, AL, Schönke, M, Chen, S, Samad, M, Altıntaş, A et al.. Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis. Cell Metab. 2019;30 (1):92-110.e4. doi: 10.1016/j.cmet.2019.03.013. PubMed PMID:31006592 .
  4. Sato, S, Parr, EB, Devlin, BL, Hawley, JA, Sassone-Corsi, P. Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle. Mol Metab. 2018;16 :1-11. doi: 10.1016/j.molmet.2018.06.008. PubMed PMID:30293576 PubMed Central PMC6157466.
  5. Sato, S, Solanas, G, Peixoto, FO, Bee, L, Symeonidi, A, Schmidt, MS et al.. Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging. Cell. 2017;170 (4):664-677.e11. doi: 10.1016/j.cell.2017.07.042. PubMed PMID:28802039 PubMed Central PMC7792549.
  6. Sato, S, Sakata, K, Hashimoto, Y, Takikawa, H, Suzuki, K. First Total Syntheses of Tetracenomycins C and X. Angew Chem Int Ed Engl. 2017;56 (41):12608-12613. doi: 10.1002/anie.201707099. PubMed PMID:28762249 .
  7. Orozco-Solis, R, Montellier, E, Aguilar-Arnal, L, Sato, S, Vawter, MP, Bunney, BG et al.. A Circadian Genomic Signature Common to Ketamine and Sleep Deprivation in the Anterior Cingulate Cortex. Biol Psychiatry. 2017;82 (5):351-360. doi: 10.1016/j.biopsych.2017.02.1176. PubMed PMID:28395871 PubMed Central PMC5660920.
  8. Natori, Y, Nasui, M, Edo, K, Sato, S, Sakurai, T, Kizaki, T et al.. NEU1 sialidase controls gene expression and secretion of IL-6 and MCP-1 through NF-κB pathway in 3T3-L1 adipocytes. J Biochem. 2017;162 (2):137-143. doi: 10.1093/jb/mvx006. PubMed PMID:28130415 .
  9. Sato, S, Jung, H, Nakagawa, T, Pawlosky, R, Takeshima, T, Lee, WR et al.. Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR. J Biol Chem. 2016;291 (20):10515-27. doi: 10.1074/jbc.M115.708982. PubMed PMID:26984404 PubMed Central PMC4865902.
  10. Kizaki, T, Sato, S, Shirato, K, Sakurai, T, Ogasawara, J, Izawa, T et al.. Effect of Circadian Rhythm on Clinical and Pathophysiological Conditions and Inflammation. Crit Rev Immunol. 2015;35 (4):261-75. doi: 10.1615/critrevimmunol.2015014925. PubMed PMID:26757391 .
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