tapasree sarkar
Tapasree Roy Sarkar

Assistant Professor

Sarkar Lab Webpage


3258 TAMU
Biological Sciences Building West
Room 233


3258 TAMU
Biological Sciences Building West
Room 233

Joined the Department in 2018

  • M.S. East Tennessee State University, TN, Biology
  • Ph.D Purdue University, IN,  Biological Engineering
  • Postdoctoral research: National Cancer Institute (NCI/NIH), M.D. Anderson Cancer Center


Co-Director, Center for Statistical Bioinformatics (2019-current)

  • Cancer Bioinformatics
  • Cancer Metabolomics
  • Nanotechnology
  • Mechanobiology

An aberrant activation of the biological process, termed epithelial-mesenchymal transition (EMT) plays an important role for the acquisition of malignant phenotypes as well as cancer stem cells (CSC) properties by epithelial cancer cells. EMT facilitates the metastatic dissemination which is the major cause of cancer related mortality. The main focus of my work is to identify the molecular mechanisms that induces EMT, and to develop novel therapeutic strategies for preventing and treating metastasis.

  1. Sarkar, M, Nguyen, T, Gundre, E, Ogunlusi, O, El-Sobky, M, Giri, B et al.. Cancer-associated fibroblasts: The chief architect in the tumor microenvironment. Front Cell Dev Biol. 2023;11 :1089068. doi: 10.3389/fcell.2023.1089068. PubMed PMID:36793444 PubMed Central PMC9923123.
  2. Nguyen, T, Maniyar, A, Sarkar, M, Sarkar, TR, Neelgund, GM. The Cytotoxicity of Carbon Nanotubes and Hydroxyapatite, and Graphene and Hydroxyapatite Nanocomposites against Breast Cancer Cells. Nanomaterials (Basel). 2023;13 (3):. doi: 10.3390/nano13030556. PubMed PMID:36770518 PubMed Central PMC9919526.
  3. Dey, S, Murmu, N, Mondal, T, Saha, I, Chatterjee, S, Manna, R et al.. Multifaceted entrancing role of glucose and its analogue, 2-deoxy-D-glucose in cancer cell proliferation, inflammation, and virus infection. Biomed Pharmacother. 2022;156 :113801. doi: 10.1016/j.biopha.2022.113801. PubMed PMID:36228369 .
  4. Maity, AK, Lee, SC, Hu, L, Bell-Pedersen, D, Mallick, BK, Sarkar, TR et al.. Circadian Gene Selection for Time-to-event Phenotype by Integrating CNV and RNAseq Data. Chemometr Intell Lab Syst. 2021;212 :. doi: 10.1016/j.chemolab.2021.104276. PubMed PMID:35068632 PubMed Central PMC8775911.
  5. Sphyris, N, King, C, Hoar, J, Werden, SJ, Vijay, GV, Miura, N et al.. Carcinoma cells that have undergone an epithelial-mesenchymal transition differentiate into endothelial cells and contribute to tumor growth. Oncotarget. 2021;12 (8):823-844. doi: 10.18632/oncotarget.27940. PubMed PMID:33889304 PubMed Central PMC8057273.
  6. Carrow, JK, Singh, KA, Jaiswal, MK, Ramirez, A, Lokhande, G, Yeh, AT et al.. Photothermal modulation of human stem cells using light-responsive 2D nanomaterials. Proc Natl Acad Sci U S A. 2020;117 (24):13329-13338. doi: 10.1073/pnas.1914345117. PubMed PMID:32461372 PubMed Central PMC7306823.
  7. Maity, AK, Lee, SC, Mallick, BK, Sarkar, TR. Bayesian structural equation modeling in multiple omics data with application to circadian genes. Bioinformatics. 2020;36 (13):3951-3958. doi: 10.1093/bioinformatics/btaa286. PubMed PMID:32369552 PubMed Central PMC7332567.
  8. Roy Sarkar, T, Maity, AK, Niu, Y, Mallick, BK. Multiple Omics Data Integration to Identify Long Noncoding RNA Responsible for Breast Cancer-Related Mortality. Cancer Inform. 2019;18 :1176935119871933. doi: 10.1177/1176935119871933. PubMed PMID:31488946 PubMed Central PMC6710679.
  9. Pearson, SJ, Roy Sarkar, T, McQueen, CM, Elswood, J, Schmitt, EE, Wall, SW et al.. ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition. Oncogene. 2019;38 (14):2611-2626. doi: 10.1038/s41388-018-0622-4. PubMed PMID:30531838 PubMed Central PMC6450754.
  10. Bollong, MJ, Pietilä, M, Pearson, AD, Sarkar, TR, Ahmad, I, Soundararajan, R et al.. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017;114 (46):E9903-E9912. doi: 10.1073/pnas.1716009114. PubMed PMID:29087350 PubMed Central PMC5699095.
  11. Sarkar T.R., Niu, Y, Mallick, B.K., Wu, G. Intakes of amino acids and other nutrients by adult humans. Adv Exp Med Biol. 2021, 1332:211-227.
  12. Maity, AK., Lee, S-C., Hu, L., Bell-Pedersen., D., Mallick, BK, Sarkar T. R. Significant Circadian Gene Selection for Time-to-event Phenotype by Integrating CNV and RNAseq Data. Chemometrics and Intelligent Laboratory Systems, 2021, 212, 104276.
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