Research Papers:

1. Carpenter, C.D., A.M. Bruskin, P.E. Hardin, M.J. Keast, J. Anstrom, A.L. Tyner, B.P. Brandhorst and W. H. Klein (1984) Novel proteins belonging to the troponin C superfamily encoded by a set of mRNA’s in sea urchin embryos. Cell 36, 663-671.

2. Hardin, S.H., C.D. Carpenter, P.E. Hardin, A.M. Bruskin and W.H. Klein (1985) Structure of the Spec1 gene encoding a major calcium-binding protein in the embryonic ectoderm of the sea urchin. J. Mol. Biol. 186, 243-255.

3. Hardin, P.E., and W.H. Klein (1987) Unusual sequence conservation in the 5’ and 3’ untranslated regions of the sea urchin Spec mRNA’s. J. Molec. Evol. 25, 126-133.

4. Hardin, S.H., M.J. Keast, P.E. Hardin and W.H. Klein (1987) Use of consensus oligonucleotides for detecting and isolating nucleic acids encoding calcium binding domains of the troponin-C superfamily. Biochemistry 26, 3518-3523.

5. Hardin, P.E., L. M. Angerer, S.H. Hardin, R.C. Angerer and W.H. Klein (1988) The Spec 2 genes of Strongylocentrotus purpuratus: Structure and differential expression in embryonic aboral ectoderm cells. J. Molec. Biol. 202, 417-431.

6. Hardin, P.E., J.C. Hall and M. Rosbash (1990) Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature 343, 536-540.

7. Zwiebel, L.J., P.E. Hardin, J.C. Hall and M. Rosbash (1991) A post-transcriptional mechanism contributes to circadian cycling of a per-ß-galactosidase fusion protein. Proc. Natl. Acad. Sci. USA 88, 3882-3886.

8. Zwiebel, L.J., P.E. Hardin, J.C. Hall and M. Rosbash (1991) Circadian oscillations in the protein and mRNA levels of the period gene of Drosophila melanogaster. Biochem. Soc. Trans. 19, 533-537.

9. Hardin, P.E., J.C. Hall and M. Rosbash (1992) Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster. EMBO J. 11, 1-6.

10. Hardin, P.E., J.C. Hall and M. Rosbash (1992) Circadian oscillations of period gene mRNA levels are transcriptionally regulated. Proc. Natl. Acad. Sci. USA 89, 11711-11715.

11. Frisch, B., P.E. Hardin, M.J. Hamblen-Coyle, J.C. Hall and M. Rosbash (1994) A promoterless DNA fragment from the period locus permits behavioral rhythmicity and mediates cyclical expression of this clock gene in a subset of the Drosophila nervous system. Neuron 12, 555-570.

12. Zeng, H., P.E. Hardin and M. Rosbash (1994) Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling. EMBO J. 13, 3590-3598.

13. Hardin, P.E. (1994) Analysis of period mRNA cycling in Drosophila head and body tissues indicates that body oscillators behave differently from head oscillators. Mol. Cell. Biol. 4, 7211-7218.

14. Qiu, J., and P.E. Hardin (1995) Temporal and spatial expression of an adult cuticle protein gene from Drosophila suggests that its protein product may impart some specialized cuticle function. Dev. Biol. 167, 416-425.

15. Qiu, J., and P.E. Hardin (1996) Developmental state and the circadian clock interact to influence the timing of eclosion in Drosophila melanogaster. J. Biol. Rhythms 11, 75-86.

16. Qiu, J., and P.E. Hardin (1996) per mRNA cycling is locked to lights-off under photoperiodic conditions that support circadian feedback loop function. Mol. Cell. Biol. 16, 4182-4188.

17. Hao, H., D.L. Allen and P.E. Hardin (1997) A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila. Mol. Cell. Biol. 17, 3687-3693.

18. Cheng, Y. and P.E. Hardin (1998) Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling. J. Neurosci. 18, 741-750.

19. Cheng, Y., B. Gvakharia and P.E. Hardin (1998) Two alternatively spliced transcripts from the Drosophila period gene rescue rhythms having different molecular and behavioral characteristics. Mol. Cell. Biol. 18, 6505-6514.

20. Hao, H., N.R.J. Glossop, L.C. Lyons, J. Qiu, B. Morrish, Y. Cheng and P.E. Hardin (1999) The period gene circadian regulatory sequence (CRS) mediates correct spatial regulation and behavioral rescue in Drosophila. J. Neurosci. 19, 987-994.

21. Krishnan, B., S.E. Dryer and P.E. Hardin (1999) Circadian rhythms in olfactory responses of Drosophila melanogaster. Nature 400, 375-378.

22. Majercak, J., D. Sidote, P.E. Hardin and I. Edery (1999) How a circadian clock adapts to seasonal decreases in temperature and day-length. Neuron 24, 219-230.

23. Glossop, N.R.J., L.C. Lyons and P.E. Hardin (1999) Interlocked feedback loops within the Drosophila circadian oscillator. Science 286, 766-768.

24. Bae, K., C. Lee, P.E. Hardin and I. Edery (2000) dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex. J. Neurosci., 20,1746-1753.

25. Kaneko, M., J.H. Park, Y. Cheng, P.E. Hardin and J.C. Hall (2000) Disruption of synaptic transmission or clock-gene-product oscillations in circadian pacemaker cells of Drosophila cause abnormal behavioral rhythms. J. Neurobiol. 43, 207-233.

26. Lyons, L.C., T.K. Darlington, S.A. Kay and P.E. Hardin (2000) Specific sequences outside of the E-box are required for proper per expression and behavioral rescue. J. Biol. Rhythms 15, 472-482.

27. Darlington, T.K, L.C. Lyons, P.E. Hardin and S.A. Kay (2000) The period E-box is sufficient to Drive Circadian Transcription in vivo. J. Biol. Rhythms 15, 462-471.

28. Posey, K.L., L.B. Jones, R. Cerda, M. Bajaj, T. Huynh, P.E. Hardin and S.H. Hardin (2001) Survey of transcripts in the adult Drosophila Brain. Genome Biology 2, 0008.1-0008.16.

29. Blanchardon, E., B. Grima, A. Klarsfeld, E. Chelot, P. E. Hardin, T. Préat and F. Rouyer (2001) Defining the role of Drosophila lateral neurons in the control of activity and eclosion circadian rhythms by targeted genetic ablation and PERIOD protein overexpression. Eur. J. Neurosci. 13, 871-888.

30. Krishnan, B., J. D. Levine, K. Sisson, H. B. Dowse, P. Funes, J. C. Hall, P. E. Hardin and S. E. Dryer (2001) A novel role for cryptochrome in a Drosophila circadian oscillator. Nature 411, 313-317.

31. Kim, E.-Y., K. Bae, F. S. Ng, N. R. J. Glossop, P .E Hardin and I. Edery (2002) Drosophila CLOCK is under post-transcriptional control and influences light-induced activity. Neuron, 34, 69-81.

32. Glossop, N. R. J., J. H. Houl, H. Zheng, F. S. Ng, S. M. Dudek and P. E. Hardin (2003) VRI feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator. Neuron 37, 249-261.

33. Cyran, S.A., A.M. Buchsbaum, K.L. Reddy, M.-C. Lin, N.R.J. Glossop, P.E. Hardin, M.W. Young, R.V. Storti and J. Blau (2003) vrille, Pdp1 and dClock form a second feedback loop in the Drosophila circadian clock. Cell 112, 329-341.

34. Smolen, P., B. S. Lo, P. E. Hardin, D. A. Baxter and J. H. Byrne (2004) A Drosophila Circadian Model Incorporating VRI, PDP-1, and CLK Simulates Mutations and Temperature Compensation. Biophys. J. 86, 2786-2802.

35. Tanoue, S., P. Krishnan, B. Krishnan, S.E. Dryer and P.E. Hardin (2004) Circadian clocks in antennal neurons are required for olfaction rhythms in Drosophila. Curr. Biol. 14, 638-649.

36. Durgan, D. J., M. A Hotze, T. M. Tomlin, O. Egbbejimi, C. Graveleau, E. D. Abel, C. A. Shaw, M. S. Bray, P. E. Hardin and M. E. Young (2005) Reactivation of the circadian clock within adult rat cardiomyocytes: Potential role in regulation of metabolic gene expression. Am. J. Physiol. Heart Circ. Physiol., 289, H1530-H1541.

37. Ge, H., P. Krishnan, L. Liu, B. Krishnan, R. L. Davis, P. E. Hardin and G. W. Roman (2005) A Drosophila non-visual arrestin is required for the maintenance of olfactory sensitivity. Chemical Senses 31, 49-62.

38. Houl, J. H., W. Yu, S. M. Dudek and P. E. Hardin (2006) Drosophila CLOCK accumulates in nuclei of circadian oscillator cells and additional non-oscillator cells at all times of the daily cycle. J. Biol. Rhythms 21, 93-103.

39. Yu, W., H. Zheng, J. H. Houl and P. E. Hardin (2006) PER dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription. Genes Dev. 20, 723-733.

40. Durgan, D.J, N. Trexler, O. Egbejimi, C.A. Shaw, M.S. Bray, P.E. Hardin, M.P. Chandler C.-W. Chow and M.E. Young (2006) The circadian clock within the cardiomyocyte modulates responsiveness of the heart to fatty acids. J. Biol. Chem. 281, 24254-24269.

41. Fujii, S., P. Krishnan, P. E. Hardin and H. Amrein (2007) Nocturnal male sex drive in Drosophila. Curr. Biol. 17, 244-251.

42. Lazareva, A., W. Mattox, P. E. Hardin and B. Dauwalder (2007) A role for the adult fat body in Drosophila male courtship behavior. PLOS Genetics 3, e16.

43. Benito, J., H. Zheng and P. E. Hardin (2007) PDP1 functions downstream of the circadian oscillator to mediate behavioral rhythms. J. Neurosci. 27, 2539-2547.

44. Kim, E. Y., H. W, Ko, W. Yu, P. E. Hardin and I. Edery (2007) A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation, transcriptional repression and circadian clock function. Mol. Cell. Biol. 27, 5014-5028.

45. Matsumoto, A., M. Ukai-Tadenuma, R. G. Yamada, J. Houl, K. D. Uno, T. Kasukawa, B. Dauwalder, T. Q. Ito, K. Takahashi, R. Ueda, P. E. Hardin, T. Tanimura and H. R. Ueda (2007) A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock. Genes Dev. 21, 1687-1700.

46. Kung, T. A., O. Egbejimi, J. Cui, N. P. Ha, D. J. Durgan, M. F. Essop, C. A. Shaw, P. E. Hardin, W. C. Stanley and M. E. Young (2007) Ischemia, but not hypoxia, rapidly attenuates circadian clock gene oscillations in the rat heart. J. Mol. Cell. Cardiol. 43, 733-753.

47. Bray, M.S., C. A. Shaw, M. W. Moore, R. A. Garcia, M. M. Zanquetta, D. J. Durgan, W. J. Jeong, J. Y. Tsai, H. Bugger, D. Zhang, A. Rohrwasser, J. H. Rennison, J. R. Dyck, S. E. Litwin, P. E. Hardin, C. W. Chow, M. P. Chandler, E. D. Abel, M. E. Young. (2008) Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol., 294, H1036-1047.

48. Zheng, H., F. S. Ng, Y. Liu and P. E. Hardin (2008) Spatial and Circadian Regulation of cry in Drosophila. J. Biol. Rhythms 23, 283-295.

49. Benito, J., J. H. Houl, G. W. Roman and P. E. Hardin (2008) The Blue Light Photoreceptor CRYPTOCHROME is Expressed in a Subset of Circadian Oscillator Neurons in the Drosophila CNS. J. Biol. Rhythms 23, 296-307.

50. Taylor, P., and P. E. Hardin (2008) Rhythmic E-box binding by CLK-CYC controls daily cycles in per and tim transcription and chromatin modifications. Mol. Cell. Biol. 28, 4642-4652.

51. Tanoue, S., A. Chatterjee, P. Krishnan and P. E. Hardin (2008) G-protein-coupled Receptor Kinase 2 is required for rhythmic olfactory responses in Drosophila. Curr. Biol. 18, 787-794.

52. Krishnan, P., A. Chatterjee and P. E. Hardin (2008) Spike amplitude and single unit responses in antennal sensillae is controlled by the Drosophila circadian clock. Curr. Biol. 18, 803-807.

53. Houl, J. H., F. Ng, P. Taylor and P. E. Hardin (2008) CLOCK expression identifies developing circadian oscillator neurons in the brains of Drosophila embryos. BMC Neurosci. 9, 119.

54. Yu, W., H. Zheng, J. L. Price and P. E. Hardin (2009) DOUBLETIME functions to bridge CLK phosphorylation by other kinases. Mol. Cell. Biol. 29, 1452-1458.

55. Chatterjee, A., G. Roman and P. E. Hardin (2009) Go contributes to olfactory reception in Drosophila melanogaster. BMC Physiology 9, 22.

56. Chatterjee, A., S. Tanoue, J. H. Houl and P. E. Hardin (2010) Regulation of gustatory physiology and appetitive behavior by the circadian clock in Drosophila melanogaster. Curr. Biol. 20, 300-309.

57. Benito, J., V. Hoxha, C. Lama, A. Lazareva, J-F. Ferveur, P. E. Hardin and B. Dauwalder (2010) The circadian output gene takeout is regulated by Pdp1. Proc. Natl. Acad. Sci. USA 107, 2544-2549.

58. Zhang, Y., Y. Liu, D. Wentworth, P. E. Hardin and P. Emery (2010) Light and temperature control the contribution of a subset of Dorsal Neurons 1 to Drosophila circadian behavior. Curr. Biol. 20, 591-599.

59. Zhang, L., B. Y. Chung, B. C. Lear, V. L. Kilman, Y. Liu, G. Mahesh, R. Meissner, P. E. Hardin and R. Allada (2010) A subset of circadian neurons coordinates light and PDF signaling to produce robust daily behavior in Drosophila. Curr. Biol. 20, 600-605.

60. Yu, W., J. H. Houl and P. E. Hardin (2011) NEMO kinase contributes to core period determination by slowing the pace of the Drosophila circadian oscillator. Curr. Biol. 21, 756-761.

61. Kaneko, H., L. M. Head, J. Ling, Y. Liu, P. E. Hardin, P. Emery, F. N. Hamada (2012) Circadian rhythm of temperature preference and its neural control in Drosophila. Curr. Biol. 22, 1851-1857.

62. Glossop, N. R. J., I. Ghangrekar, G. A. Coutts, P. E. Hardin, J. O. Gummadova (2014) TWIN-OF-EYELESS (TOY) functions directly upstream of Clock to initiate and maintain circadian fate in central pacemaker cells that coordinate sleep-wake cycles. J. Biol. Rhythms 29, 151-166.

63. Mahesh, G., E. H. Jeong, F. S. Ng, Y. Liu, K. Gunawardhana, J. H. Houl, E. Yildirim, R. Amunugama, R. Jones, D. L. Allen, I. Edery, E. Y. Kim and P. E. Hardin (2014) Phosphorylation of the transcription activator CLOCK regulates progression through a ~24h feedback loop to influence circadian period in Drosophila. J. Biol. Chem. 289, 19681-93.

64. Lee, E., E. H. Jeong, H. J. Jeong, E. Yildirim, J. T. Vanselow, F. S. Ng, Y. Liu, G. Mahesh, A. Kramer, P. E. Hardin, I. Edery and E. Y. Kim (2014) Phosphorylation of a central clock transcription factor is required for thermal but not photic entrainment. PLOS Genetics 10, e1004545.

65. Liu, T., G. Mahesh, J. H. Houl and P. E. Hardin (2015) Circadian activators are expressed days before they initiate clock function in late pacemaker neurons from Drosophila. J. Neurosci. 35, 8662-8671.

66. Agrawal, P. and P. E. Hardin (2016) The Drosophila receptor protein tyrosine phosphatase LAR is required for development of circadian pacemaker neuron processes that support rhythmic activity in constant darkness but is not required for activity rhythms during light:dark cycles. J. Neurosci. 36, 3860-3870.

67. Zhou, J., W. Yu and P. E. Hardin (2016) CLOCKWORK ORANGE enhances PERIOD mediated rhythms in transcriptional repression by antagonizing E-box binding by CLOCK-CYCLE. PLoS Genet. 12, e1006430.

68. Agrawal, P. and P. E. Hardin (2016) An RNAi screen to identify protein phosphatases that function within the Drosophila circadian clock. G3 (Bethesda), 6:4227-4238.

69. Agrawal, P., J. H. Houl, K. Gunawardhana, T. Liu, J. Zhou, Mark J. Zoran and Paul E. Hardin (2017) Drosophila CRY entrains clocks in body tissues to light and maintains passive membrane properties in a non-clock body tissue independent of light. Curr Biol. 27, 2431-2441.

70. Zhang Y., M. J. Markert, S. C. Groves, P. E. Hardin and C. Merlin (2017) Insect vertebrate-like CRYPTOCHROME2 regulates circadian transcription through additive mechanisms on CLOCK and BMAL1. PNAS 114, E7516-E7525.

71. Liu T., G. Mahesh, W. Yu, and P. E. Hardin (2017) CLOCK stabilizes CYCLE to initiate clock function in Drosophila. PNAS 114, 10972-10977.

72. Gunawardhana K. and P. E. Hardin (2017) VRILLE controls PDF neuropeptide accumulation and arborization rhythms in small ventrolateral neurons to drive rhythmic behavior in Drosophila. Curr Biol. 27:3442-3453.

73. Chatterjee A., A. Lamaze A., J. De, E. Chelot, B. Martin, P. E. Hardin, S. Kadener, P. Emery and F. Rouyer (2018) Reconfiguring a multi-oscillator network by light in the Drosophila circadian clock. Curr Biol., 28:2007-2017.

74. Fuentes N.R., M. Mlih, R. Barhoumi, P. E. Hardin, T. Steele, S. Behmer, I. Prior, E. R. Fearon, J. Karpac and R. S. Chapkin (2018) Long chain n-3 fatty acids attenuate oncogenic Ras driven proliferation by altering plasma membrane protein nanoclustering. Cancer Res., 78:3899-3912.

75. Mahesh, G., G. B. S. Rivas, C. Caster, E. B. Ost, R. Amunugama, R. Jones, D. L. Allen and P. E. Hardin (2020) Proteomic analysis of Drosophila CLOCK complexes identifies rhythmic interactions with SAGA and Tip60 complex component NIPPED-A. Sci. Rept., 10: 17591.

76. Gunawardhana K., G. B. S. Rivas, C. Caster and P. E. Hardin (2020) Crosstalk between vrille transcripts, proteins and regulatory elements controlling circadian rhythms and development in Drosophila. iScience 24, 101893.

77. Rivas G. B. S., J. Zhou, C. Merlin and P. E. Hardin (2021) CLOCKWORK ORANGE promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of CLOCK INTERACTING PROTEIN CIRCADIAN. Curr Biol. 31, 4207-4218.

78. Zhang, Y., S. E. Iiams, J. S. Menet, P. E. Hardin and C. Merlin (2022) TRITHORAX-dependent arginine methylation of HSP68 mediates circadian repression by PERIOD, PNAS 119, e2115711119.

79. Yin, J. C. P., E. Cui, P. E. Hardin and H. Zhou (2023) Circadian Disruption of Memory Consolidation in Drosophila. Front. Syst. Neurosci. 17, 1129152

Reviews, Book Chapters and Symposia Proceedings:

1. Klein, W.H., P.E. Hardin, S.H. Hardin and C. Flytzanis (1987) Structure and expression of the sea urchin Spec genes. In Proceedings of the Fifth International Symposium on Calcium Binding Proteins in Health and Disease (A.W. Norman, T.C. Vanaman and A.R. Means, eds.) Academic Press, San Diego, CA. pp. 243-249.

2. Hardin, P.E., J.C. Hall and M. Rosbash (1992) Circadian oscillations in the protein and mRNA levels of the period gene of Drosophila melanogaster. In Molecular Genetics of Biological Rhythms (M.W. Young, ed.) Marcel Dekker, New York. pp. 155-169.

3. Hardin, P.E. (1994) The molecular genetics of biological rhythms. In Encyclopedia of Time (S.L Macey, ed.) Garland Publishing, New York. pp. 400-401.

4. Hardin, P.E., and K. K. Siwicki (1995) The multiple roles of per in the Drosophila circadian clock. Semin. Neurosci. 7:15-25.

5. Hardin, P. E. and A. Sehgal (1998) Molecular Components of a Model Circadian Clock: Lessons from Drosophila. In Handbook of Behavioral State Control: Molecular and Physiological Mechanisms (R. Lydic and H. Baghdoyan, eds.) CRC Press, Boca Raton, FL. pp. 61-74.

6. Hardin, P. E. (1998) Activating inhibitors and inhibiting activators: A day in the life of a fly. Curr. Opin. Neurosci. 8:642-647.

7. Dryer, S. E., B. Krishnan and P. E. Hardin (1999) Circadian clocks regulate olfactory responses. ChemoSense 1:1-3.

8. Hardin, P.E and N.R.J. Glossop (1999) Shedding light on the CRYs of flies and mice. Science 286:2460-2461.

9. Hardin, P.E. (2000) From biological clock to biological rhythms. Genome Biology 1, 1023.1-1023.5.

10. Hardin, P.E, N.R.J. Glossop, L.C. Lyons, B. Krishnan and S.E. Dryer (2001) The Drosophila circadian oscillator: Molecular circuits and rhythmic outputs. In Zeitgebers, Entrainment and Masking of the Circadian System (K. Honma and S. Honma, eds.) Hokkaido University Press, Sapporo, pp. 77-88.

11. Glossop, N.R.J. and P.E. Hardin (2002) Central and peripheral circadian oscillator mechanisms in flies and mammals. J. Cell Science 115:3369-3377.

12. Hardin, P.E, B. Krishnan, J.H. Houl, H. Zheng, F.S. Ng, S.E. Dryer and N.R.J. Glossop (2003) Central and peripheral circadian oscillators in Drosophila. Novartis Found. Symp. 253:140-150.

13. Hardin, P.E. (2003) Central and peripheral oscillator mechanisms in flies. Cell Technology 22:1315-1319.

14. Hardin, P. E. (2004) Transcription regulation within the circadian clock: The E-box and beyond. J. Biol. Rhythms 19:348-360.

15. Hardin, P.E. (2005) The circadian system of Drosophila. In Biological Rhythms (K. Honma and S. Honma, eds.) Hokkaido University Press, Sapporo, pp. 3-16.

16. Krishnan, P., S. E. Dryer and P. E. Hardin (2005) Measuring circadian rhythms in olfaction using electroantennograms. Meth. Enz. 393:495-508.

17. Bell-Pedersen, D., V. M. Cassone, D. J. Earnest, S. S. Golden, P. E. Hardin, T. L. Thomas and M. J. Zoran (2005) Multiple oscillators regulate rhythmicity in organisms from bacteria to man. Nat. Rev. Genet. 6:544-56.

18. Hardin, P. E. (2005) The Circadian Timekeeping System of Drosophila. Curr. Biol. 15: R714-R722.

19. Hardin, P. E., and W. Yu (2006) Circadian Transcription: Passing the HAT to CLOCK. Cell 125:424-426.

20. Yu, W., and P. E. Hardin (2006) Circadian Timekeeping Mechanisms in Animals. J. Cell Sci. 119:4793-4795.

21. Hardin, P. E. (2006) Essential and expendable features of the circadian timekeeping mechanism. Curr. Opin. in Neurobiol. 16:686-692.

22. Yu, W., and P. E. Hardin (2007) Use of firefly luciferase assays to monitor circadian molecular rhythms in vivo. In Methods in Molecular Biology (E. Rosato, ed.) Humana Press, Inc., New Jersey, vol. 362:465-480.

23. Benito, J., H. Zheng, F. S. Ng and P. E. Hardin (2007) Transcriptional feedback loop regulation, function and ontogeny in Drosophila. Cold Spring Harbor Sym. Quant. Biol., 72:437-444.

24. Hardin, P. E. (2009) Molecular Mechanisms of circadian timekeeping in Drosophila. Sleep Biol. Rhythms 7:235-242.

25. Chatterjee, A. and P. E. Hardin (2010) Time to taste: Circadian clock function in the Drosophila gustatory system. FLY 4:283-287.

26. Hardin, P. E. (2011) Molecular genetic analysis of circadian timekeeping in Drosophila. Adv. Genetics 74:141-173.

27. Hardin, P. E. and S. Panda (2013) Circadian timekeeping and output mechanisms in animals. Curr. Opin. in Neurobiol. 23, 724-731.

28. Menet, J. S. and P. E. Hardin (2014) Circadian clocks: The tissue is the issue. Curr. Biol. 24:R25-R27.

29. Zhou, J., W. Yu and P. E. Hardin (2015) ChIPping away at the Drosophila clock. Meth. Enz., 551:323-347.

30. Siwicki, K., P. E. Hardin and J. L. Price (2018) Reflections on contributing to “big discoveries” about the fly clock: Our fortunate paths as post-docs with 2017 Nobel laureates Jeff Hall, Michael Rosbash, and Mike Young. Neurobiol. Sleep Circ. Rhythms 5:58-67.

31. Hardin, P. E. (2019) The function of interlocked transcriptional feedback loops in the circadian clock. In Proceedings of the Sapporo Symposium on Biological Rhythms (K. Honma and S. Honma, eds.), pp 13-26.

32. Eskin, M., A. Eskin, P. Hardin, S. Hattar, C. Johnson and T. Page (2022) In Memorium: Arnold Eskin. J. Biol. Rhythms 36:105-108.